PEPTIDE SYNTHESIS - AMINO ACID ANALYSIS FACILITY

请求提供资金，用于购置一台自动化肽合成仪和一台氨基酸分析仪。 分析仪，以取代老化单位在阿肯色州大学。 的 所要求的设备将使六名主要调查员受益， 阿肯色州大学化学与生物化学系 以及康奈尔大学医学院的两位合作者。 九 正在进行的研究项目集中在膜蛋白相互作用，离子 通过膜通道的运输，膜通道的结构， 电子转移反应机理，质子转移机理 反应和蛋白质-蛋白质相互作用。 校园里的其他人 社区将受益于合成器的可用性， 和毒素类似物，以及用于单克隆抗体的肽抗原。 抗体设施的阿肯色州生物技术中心，并从 分析仪的可用性，用于表征新分离的 各种来源的蛋白质。

Funds are requested for an automated peptide synthesizer and amino acid analyzer to replace aging units at the University of Arkansas. The requested equipment will benefit six major investigators in the Department of Chemistry and Biochemistry at the University of Arkansas and two collaborators at Cornell University Medical College. Nine ongoing research projects focus on membrane protein interactions, ion transport through membrane channels, structures of membrane channels, mechanisms of electron transfer reactions, mechanisms of proton transfer reactions, and protein-protein interactions. Others in the campus community will benefit from the availability of a synthesizer for hormone and toxin analogues, and for peptide antigens for use at the monoclonal antibody facility of the Arkansas Biotechnology Center, and from the availability of an analyzer for characterization of newly isolated proteins from a variety of sources.