CENTER FOR DEVELOPMENTAL IMMUNOLOGY AND HOST DEFENSE

杜克大学提议建立一个研究 发育免疫学和宿主防御。免疫紊乱起着重要的作用 在儿童的许多疾病中起主要作用，传染病是 最突出的例子。在正常的宿主防御INFEC期间- 造成伤害的反应因素可能会影响正常 组织功能。免疫调节紊乱与 自身免疫性和过敏性疾病的发展。遗传性疾病 主机防御系统的几乎所有组件都已经 描述。该中心将有许多组成部分。总括 该部门的主席将提供指导 迈克尔·M·弗兰克，医学博士，公认的儿科专家 组织损伤的调解人，他们将担任首席调查员。 直接的日常监督将由丽贝卡·巴克利提供， 领先的儿科细胞免疫学家。该中心的一个主要组成部分 将是一个核心实验室，将由路易丝·马克特，医学博士， 博士，他是一位分子生物学家，在 淋巴细胞发育和控制以及巴克利博士所著。其核心是 将提供实验室并配备用于使用分子的研究 生物、化学和细胞技术。这一核心设施将 考虑到初级学员的培训和部分研究 由该计划支持的教职员工调查人员。这些儿科医生 都将在完成培训的三年内完成。它是 打算挑选一名更高级的初级教职调查员 争取更多的支持和更大程度的独立。部分内容 中心建议书涉及确定和招聘合适的 潜在的儿科调查员。一个候选人池驻留在 杜克大学实习和奖学金计划的参与者，大多数 其中一些人进入了学术儿科。技术也得到了发展。 以确定和吸引目前不属于公爵的个人 计划，包括少数族裔候选人。成功的计划 应聘者包括广泛的科学领域的培训， 是免疫学和宿主防御过程的一部分。这些低年级学生 研究人员将在Well的实验室里呆上两到三年 杜克大学社区中已知的和公认的调查员 这个大体区域。在这个角色中，他们将接受基本的 他们所在领域的科学。该计划的目的是开发 这一领域的独立年轻临床科学家，他们可以获得 杜克大学的学术任命和独立实验室支持 其他地方。对这一任命的保证将是一种强有力的 进入这一领域的儿科学术研究的诱因，那里有 目前在全国范围内有非常大的需求。

Duke University proposes to establish a Center for the Study of Developmental Immunology and Host Defenses. Disorders of immunity play a major role in many diseases of children, with infectious disease being the most prominent example. During normal host defense against infec- tion, damage-producing elements of the response may impact on normal tissue function. Disorders of immunoregulation are associated with the development of autoimmune and allergic diseases. Genetic diseases of almost all of the components of the host defense system have been described. The Center will have a number of components. Overall direction will be provided by the Chairman of the Department of Pediatrics, Michael M. Frank, M.D., a recognized expert in the area of mediators of tissue damage, who will act as Principal Investigator. Direct day to day supervision will be provided by Rebecca Buckley, a leading pediatric cellular immunologist. A major component of the Center will be a core laboratory which will be directed by Louise Markert, M.D., Ph.D., a molecular biologist with demonstrated expertise in the area of lymphocyte development and control and by Dr. Buckley. The core laboratory will be supplied and equipped for studies using molecular biological, chemical and cellular techniques. This core facility will allow for both training and a portion of the research of the junior faculty investigators supported by this program. These pediatricians will all be within three years of completing their training. It is intended that one more advanced junior faculty investigator be singled out for more support and a greater measure of independence. Part of the Center proposal involves identification and recruitment of suitable potential pediatric investigators. One pool of candidates resides in the participants in the Duke residency and fellowship programs, the majority of whom enter academic pediatrics. Techniques have also been developed to identify and attract individuals not currently part of the Duke program, including minority candidates. The program for successful candidates includes training in a broad array of scientific areas that are part of the immunologic and host defense process. These junior investigators will spend two to three years in the laboratory of well known and established investigators in the Duke community who work in this general area. In this role, they will become trained in the basic science of their field. The purpose of the program is to develop independent young clinical scientists in this field who can then gain academic appointments and independent laboratory support at Duke or elsewhere. An assurance of such an appointment will be a powerful inducement for entering academic pediatrics in this area, where there is currently a very great need nationwide.