MOLECULAR CELL BIOLOGY IN PEDIATRIC RESEARCH

我们建议建立一个儿童健康研究中心， 儿科教师发展基础科学研究技能，这将是 应用于儿童重要健康问题的研究。 中央 中心的主题将是原理和技术的应用 分子细胞生物学的研究，以广泛的， 临床儿科问题。 该中心将由16个临床 教师（10名医学博士，1名医学博士/博士和5名博士）和13名基础科学教师（11名博士， 2 MD），他们都是资金充足的既定研究人员。 临床 教师来自儿科15，医学1和基础科学 微生物学/免疫学7，麻醉学 （生物生理学/生物物理学2、生物化学1）、细胞生物学2和 生理学/生物物理学1. 这所学院在世界上有着广泛的互动， 过去在研究和训练。 临床教师是严重 在传染病和免疫学以及基础科学方面， 微生物学，因为他们过去在研究和培训方面的生产力。 虽然我们计划在自然界培养年轻的教师调查员， 先天性和围产期感染的病史、发病机制和治疗 和其它儿科感染（病毒、细菌、原生动物、支原体， 衣原体）和免疫学（发育，一般和免疫遗传学），我们 不会只集中在这些领域。 我们将开发 使用最先进技术研究各种器官系统疾病的研究人员 分子细胞生物学方法。 我们的中心将支持 以分子细胞为中心主题的平衡儿科研究 生物学作为一种联系。 为了节省研究项目的资金，我们将利用现有的和 共享儿科实验室以及5个已建立的多学科 中心核心实验室。 儿科系的科学主任 将被任命谁将帮助评估这些实验室，并评估他们的 使用和价值，以及提供培训和技术援助， 年轻的教师。 他沿着项目主任和校长 调查员和一个咨询委员会将监督 候选人的研究支持和中心的运作。 那里 来自不同学科的大量年轻教师可以 候选人中心的支持和19人，我们计划在未来招聘 三年 目前已经有12名年轻教师（从7名 亚专业）参与研究与该中心的建议 教师。

We propose to develop a Child Health Research Center to allow young pediatric faculty to develop basic science research skills which will be applied to the study of important health problems in children. The central theme of the Center will be the application of the principals and technics of molecular cell biology to the investigations of a broad range of clinical pediatric problems. The Center will be composed of 16 clinical faculty (10 MD, 1 MD/PhD and 5 PhD) and 13 basic science faculty (11 PhD, 2 MD), all of whom are well funded established investigators. The clinical faculty are drawn from Pediatrics 15, Medicine 1, and the basic science faculty from Microbiology/Immunology 7, Anesthesiology (Biophysiology/Biophysics 2, Biochemistry 1), Cell Biology 2 and Physiology/Biophysics 1. This faculty has had extensive interaction in the past in both research and training. The clinical faculty is heavily weighted in infectious disease and immunology and the basic sciences in microbiology because of their past productivity in research and training. Though we plan to develop young faculty investigators in the natural history, pathogenesis and treatment of congenital and perinatal infections and other pediatric infections (viruses, bacterial, protozoa, mycoplasma, chlamydia) and in immunology (developmental, general and immunogenetics) we will not concentrate exclusively in these areas. We will develop investigators who study various organ systems diseases using state of art molecule cell biology approaches. In this way our Center will support balanced pediatric research using the central theme of Molecular Cell Biology as a link. To conserve funds for research projects we will utilize established and shared pediatric laboratories as well as 5 established multidisciplinary Center Core laboratories. A scientific director from the pediatric faculty will be appointed who will help assess these laboratories and assess their use and value, as well as providing training and technical assistance to the young faculty. He along with the Program Director and Principal Investigator and an Advisory Committee will oversee the selection of candidates for research support and the functioning of the Center. There is a large pool of young faculty from different disciplines who can be candidates for Center support and 19 others we plan to recruit in the next three years. Already 12 of the current young faculty (from 7 subspecialties) are involved in research with the Center's proposed faculty.