PILOT--EFFECT OF GH ON NITROGEN RETENTION DURING INTRADIALYTIC HYPERALIMENTATION

慢性维持性血液透析患者的营养状况 现在在多项研究中表明是主要因素之一 预测随后的发病率和死亡率。贫困患者 透析时的营养摄入有负的氮平衡，一直以来 显示为心血管事件的高危人群和严重的 感染性并发症。大量的这些高危患者 在任何慢性透析人群中都很容易识别。 在这项研究中，我们建议调查两种营养方面的方法 在这一患者群体中补充。一种是使用肠外氨基 在透析过程中单独输注酸和葡萄糖，另一种是 补充外源生长激素。双臂的完成 这项研究的结果可能会给我们提供关于 透析患者逆转分解代谢过程。智能网的发展 产生正氮平衡的有效治疗方式可以 对患者的发病率和死亡率有重大影响。 动物研究表明，这是一种潜在的治疗形式。这个 证明合成代谢作用增强(或分解代谢作用减弱) 透析患者人群中生长激素的水平可能会很高 对透析患者发病率和存活率的影响，特别是对 所有这些都是针对营养摄入不足的普通患者。

The nutritional status of patients on chronic maintenance hemodialysis has now been shown in multiple studies to be one of the major factors predictive of subsequent morbidity and mortality. Patients with poor nutrition intake on dialysis have a negative nitrogen balance and have been shown to be at high risk for cardiovascular events and for serious infectious complications. A large population of these high risk patients are readily identifiable in any chronic dialysis population. In this study, we propose to investigate two approaches to nutritional supplementation in this patient population. One is to use parenteral amino acids and glucose infusions alone during dialysis and the other is to supplement this with exogenous growth hormone. The completion of both arms of this study will potentially yield new information about the ability of dialysis patients to reverse a catabolic process. The development of an effective treatment modality that results in positive nitrogen balance can have a major impact on patient morbidity and mortality. Animal studies suggest that this is a potential form of therapy. The demonstration of increased anabolic (or even decreased catabolic) effects of growth hormone in the dialysis patient population could have enormous impact on dialysis patient morbidity and survival, particularly for those all to common patients with poor nutritional intake.