ROLE OF ANGIOTENSIN II ON REGULATION OF ENDOTHELIN EXCRETION

内皮素（ET）是近年来发现的一种多肽， 最强的血管收缩剂 它被发现在大量的， 与血浆中的低水平相比。 虽然很多事情 虽然人们对ET的结构和生物学效应了解甚少， 关于其尿液排泄的调节（UETV）。 我们正在研究1）血管紧张素II（AII）的作用， 在正常志愿者的UETV上的苯丙氨酸（PHE）。 我们以3 ng/kg/min的速率开始AII输注，并滴定至 平均动脉血压升高至少20 mmHg，持续60 分钟 所需的AII的量平均为11.7 ng.kg/min。 洗脱期，PHE以1 μ g/kg/min的速率开始，并滴定至 目标血压相同 所需的平均PHE为2.5 mug/kg/min。 在最初的30分钟内，所有人的尿流（UV）和UETV都增加了一倍， 在过去的30分钟内下降到基线水平。 PHE大致 在前30分钟内，尿流量增加8倍，UETV增加7倍 在最后30分钟内恢复到接近基线。

Endothelin (ET), a recently discovered peptide, has been found to be the most potent vasoconstrictor known to men. It is found in high amounts in the urine compared to low levels in the plasma. Although much has been learned about the structure and biological effects of ET, little is known about the regulation of its urinary excretion (UETV). We are investigating 1) the effects of angiotensin II (AII) and Phenylephrine (PHE) on the UETV in normal volunteers. We started AII infusion at a rate of 3 ng/kg/min and titrated to an increase in mean arterial blood pressure of at least 20 mmHg for 60 minutes. The amount of AII required averaged 11.7 ng.kg/min. After a washout period, PHE was started at a rate of 1 mug/kg/min and titrated to same target blood pressure. The average PHE required was 2.5 mug/kg/min. AII roughly doubled urine flow (UV) and UETV in the initial 30 minutes, dropping back to baseline level in the last 30 minutes. PHE roughly increased urine flow by 8 fold and UETV by 7 fold in the first 30 minutes returning to close to baseline in the final 30 minute period.