RECOVERY & REGENERATION AFTER SPINAL NEURON INJURY

一项研究计划要求延长五年的支持 与脊椎动物脊髓神经元损伤有关。这位将军 该计划项目的目标仍然是深入了解 与再生有关的基本机制的性质 脊髓神经元损伤后的神经突起和/或功能恢复。 这些项目解决了从冷状态下的功能恢复等一系列问题 血液脊椎动物到哺乳动物的临床综合征模型。这个 项目的方法是多学科的，结合了生理学。 形态和组织化学/分子技术。大多数项目 从前几年支助期间取得的成果中得出结论。 其中三个项目(2、3和6)针对的是 脊柱损伤后骨骼或自主神经运动功能的变化 神经元。两个项目(1和2)涉及感官改变的机制 中枢或外周传入通路损伤后的功能。一 项目(5)检查了下列原因引起的疼痛状态的可能性 周围神经损伤可能是由于 交感传入和伤害性传入。 虽然六个项目中的每个项目都将由一个独立的团队执行 调查人员的共同利益，两个团队对 损伤脊髓神经元，使用许多相同的技术，并依赖于 核心设施，以实现其研究目标。

Renewal of support for five years is requested for a program of research related to injury of neurons of the vertebrate spinal cord. The general goal of this program project continues to be to gain insight into the nature of the fundamental mechanisms associated with regeneration of neurites and/or functional recovery after injury to spinal cord neurons. The projects address issues ranging from functional recovery in cold blooded vertebrates to mammalian models of clinical syndromes. The projects are multidisciplinary in approach, combining physiological. morphological and histochemical/molecular techniques. Most of the projects derive from results obtained during previous years of support. Three of the projects (2, 3, and 6) are directed at the nature or basis of changes in motor function, skeletal or autonomic, after injury of spinal neurons. Two projects (1 and 2) concern the mechanisms of altered sensory function following injury to central or peripheral afferent pathways. One project (5) examines the possibility that causalgic states following peripheral nerve injury may result from altered interactions between sympathetic efferents and nociceptive afferents. While each of the six projects will be carried out by an independent team of investigators, the teams share a common interest in the consequences of injury to spinal neurons, use many of the same techniques, and depend on core facilities to accomplish their research goals.