MODULATION OF HUMAN LIPOPROTEIN METABOLISM BY ESTROGEN

西方长寿性别差异的生物学基础 社会代表着一种在我们老龄化过程中日益重要的现象 这是这个调查小组的主要兴趣所在。差一点 这种差异的一半可归因于 动脉粥样硬化和这其中的大部分反过来又是性别差异 脂蛋白脂质水平，其中大部分可在绝经后复制 接受雌激素替代疗法(有或没有孕激素)的妇女 代理)。然而，监管的确切机制和要点 性激素(雄激素和雌激素)调节人体脂蛋白 人们对新陈代谢的定义还只有一部分。此外，对该类型的研究 提出的建议有可能为以下几点的研究提供信息 人体正常脂蛋白代谢的调节。因此，目的是 这项建议是为了测试雌激素替代对两个人的影响， 脂蛋白代谢的相关方面： 1.反转胆固醇通过“脂质转移区”， 测定胆固醇酯转移活性和蛋白(CETP)和载脂蛋白 免疫测定法测定载脂蛋白E及脂质和载脂蛋白的分布 E跨越IDL-低密度脂蛋白-高密度脂蛋白连续体系； 2.高密度脂蛋白及其载脂蛋白的周转 和亚组分，特别是肝素后的活性 甘油三酯脂肪酶(HTGL)和CETP。

The biological basis for the sex differential in longevity in Western societies represents a phenomenon of increasing importance in our aging society and is the primary interest of this investigative team. Nearly half of this differential is attributable to the sex differential in atherosclerosis and the majority of this in turn to the sex differential in lipoprotein lipid levels, much of which can be reproduced in postmenopausal women given estrogen replacement therapy (with or without progestational agents). However, the precise mechanisms and points of regulation at which sex steroids (androgens as well as estrogens) modulate human lipoprotein metabolism have been only partially defined. Moreover, studies of the type proposed have the potential of informing research on the points of regulation of normal human lipoprotein metabolism. Hence the purpose of this proposal is to test the effects of estrogen replacement on two, related aspects of lipoprotein metabolism: 1. Reverse cholesterol transport through the "lipid transfer zone", measuring cholesterol ester transfer activity and protein (CETP) and apo- lipoprotein (apo) E by immunoassay and the distribution of lipids and apo E across the IDL-LDL-HDL continuum; 2. The turnover of high density lipoprotein (HDL), its apolipoproteins and subfractions, with special reference to the activity of post-heparin triglyceride lipase (HTGL) and CETP.