SEX STEROID MODULATION OF HUMAN LIPOPROTEIN METABOLISM
SEX STEROID MODULATION OF HUMAN LIPOPROTEIN METABOLISM
批准号:
3354334
负责人:
WILLIAM R HAZZARD
金额:
$15.48万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-06-01 至 1990-11-30
关键词:
androgens apolipoproteins blood lipid blood lipoprotein metabolism electrofocusing estrogens familial hyperlipoproteinemia type II familial hyperlipoproteinemia type III female gel filtration chromatography gender difference high density lipoproteins hormone regulation /control mechanism hormone therapy human subject lipoprotein disorder lipoprotein lipase low density lipoprotein mathematical model radioimmunoassay receptor steroid hormone triacylglycerol lipase ultracentrifugation very low density lipoprotein
中文摘要
探讨脂蛋白代谢中性别差异的机制
(反过来,动脉粥样硬化症和长寿方面的性别差异
在西方社会中),外源性雌激素(乙炔雌二醇
[EE],1微克/公斤/天)或雄激素(司坦唑醇[Sz],6毫克/天)
用于绝经后血脂正常和血脂异常的患者
女人。血脂、脂蛋白(极低密度脂蛋白、
HDL2、HDL3)、载脂蛋白(A-I、A-II、B-100、E)
放射性碘化甘油三酯脂肪酶(HTGL)和脂蛋白脂肪酶(LPL)
载脂蛋白周转率(极低密度脂蛋白载脂蛋白B、载脂蛋白E、载脂蛋白A-I和载脂蛋白A-II)
代谢性等卡路里患者在性激素治疗前和治疗期间进行的检查
日粮为40%F、45%CHO、15%P,P/S 0.8,胆固醇450 mg/d。
将进行多间隔数学建模,以分析
基础状态下脂蛋白代谢的调节及其调控
通过雌激素和雄激素使用稳态示踪研究的结果来
非稳态未标记脂质、脂蛋白和
肝素后甘油三酯脂肪酶数据。更多的见解将是
由性激素对低密度脂蛋白亚组分影响的类似研究提供
环己二酮修饰低密度脂蛋白与未修饰低密度脂蛋白的分解代谢动力学
(研究低密度脂蛋白受体与清道夫途径),以及平行研究
具有良好特征的血脂异常的妇女,值得注意的是
Apo-E2纯合子表型(III型)的高脂蛋白血症
高脂蛋白血症)或其他载脂蛋白E表型(以及IIa、IIb或
IV脂蛋白模式)与低密度脂蛋白受体缺乏的妇女(家族性
高胆固醇血症,纯合子或杂合子)。
英文摘要
To probe the mechanism of the sex differential in lipoprotein metabolism
(and in turn the sex differential in atheroslcerosis and indeed longevity
itself in Occidental societies), exogenous estrogen (ethinyl estradiol
[EE], 1 mcg/kg/d) or androgen (stanozolol [Sz], 6 mg/d) will be
administered to normolipidemic post-menopausal and dyslipoproteinemic
women. Paired studies of plasma lipids, lipoproteins (VLDL, IDL, LDL,
HDL2, HDL3), apolipoproteins (A-I, A-II, B-100, E) post-heparin hepatic
triglyceride lipase (HTGL) and lipoprotein lipase (LPL), radio-iodinated
apolipoprotein turnover (VLDL apo-B, apo-E, apo-A-I and A-II) will be
performed before and during sex steroid treatment on a metabolic isocaloric
diet of 40% F, 45% CHO, 15% P, P/S 0.8, cholesterol 450 mg/d.
Multicompartmental mathematical modelling will be performed to analyze the
regulation of lipoprotein metabolism in the basal state and its modulation
by estrogen and androgen using results of steady state tracer studies to
constrain modeling of non-steady state unlabeled lipid, lipoprotein, and
post-heparin triglyceride lipase data. Additional insights will be
afforded by similar studies of sex steroid effects on LDL subfraction
kinetics, the catabolism of cyclohexanedione-modified vs. unmodified LDL
(to examine LDL-receptor vs. scavenger pathways), and parallel studies of
women with well-characterized dyslipoproteinemias, notably
hyperapobetalipoproteinemia of homozygous apo-E2 phenotype (Type III
hyperlipoproteinemia) or of other apo-E phenotypes (and Types IIa, IIb, or
IV lipoprotein patterns) and women with LDL-receptor deficiency (familial
hypercholesterolemia, homozygous or heterozygous).
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
A rapid and sensitive micro-assay for the enzymatic determination of plasma and lipoprotein cholesterol.
一种快速、灵敏的微量测定法,用于酶法测定血浆和脂蛋白胆固醇。
DOI:
--
发表时间:
1990
期刊:
Journal of lipid research
影响因子:
6.5
作者:
[Auerbach,BJ, Parks,JS, Applebaum-Bowden,D]
通讯作者:
Applebaum-Bowden,D
A dose-response relationship between sex hormone-induced change in hepatic triglyceride lipase and high-density lipoprotein cholesterol in postmenopausal women.
绝经后妇女性激素引起的肝甘油三酯脂肪酶和高密度脂蛋白胆固醇变化之间的剂量反应关系。
DOI:
10.1016/0026-0495(91)90129-k
发表时间:
1991
期刊:
Metabolism: clinical and experimental
影响因子:
--
作者:
[ColvinJr,PL, Auerbach,BJ, Case,LD, Hazzard,WR, Applebaum-Bowden,D]
通讯作者:
Applebaum-Bowden,D
Differential effects of oral estrone versus 17 beta-estradiol on lipoproteins in postmenopausal women.
口服雌酮与 17 β-雌二醇对绝经后妇女脂蛋白的不同影响。
DOI:
10.1210/jcem-70-6-1568
发表时间:
1990
期刊:
The Journal of clinical endocrinology and metabolism
影响因子:
--
作者:
[ColvinJr,PL, Auerbach,BJ, Koritnik,DR, Hazzard,WR, Applebaum-Bowden,D]
通讯作者:
Applebaum-Bowden,D
DATABASES IN GERIATRIC CARDIOVASCULAR DISEASE AND STROKE
-
批准号:2885493
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1999
-
负责人:WILLIAM R HAZZARD
-
依托单位:
STUDY SECTION CHAIRMANS FUND (NIH)
-
批准号:3554122
-
项目类别:
-
资助金额:$98.3万
-
财政年份:1992
-
负责人:WILLIAM R HAZZARD
-
依托单位:
STUDY SECTION CHAIRMANS FUND (NIH)
-
批准号:2049032
-
项目类别:
-
资助金额:$6.25万
-
财政年份:1992
-
负责人:WILLIAM R HAZZARD
-
依托单位:
STUDY SECTION CHAIRMANS FUND (NIH)
-
批准号:2049031
-
项目类别:
-
资助金额:$7.64万
-
财政年份:1992
-
负责人:WILLIAM R HAZZARD
-
依托单位:
CLAUDE D PEPPER OLDER AMERICANS INDEPENDENCE CENTER
-
批准号:3108078
-
项目类别:
-
资助金额:$142.77万
-
财政年份:1991
-
负责人:WILLIAM R HAZZARD
-
依托单位:
APPALACHIAN GERIATRIC EDUCATION CENTER
-
批准号:3016742
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1989
-
负责人:WILLIAM R HAZZARD
-
依托单位:
APPALACHIAN GERIATRIC EDUCATION CENTER
-
批准号:3016740
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1989
-
负责人:WILLIAM R HAZZARD
-
依托单位:
APPALACHIAN GERIATRIC EDUCATION CENTER
-
批准号:3016743
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1989
-
负责人:WILLIAM R HAZZARD
-
依托单位:
SEX STEROID MODULATION OF HUMAN LIPOPROTEIN METABOLISM
-
批准号:3354333
-
项目类别:
-
资助金额:$14.07万
-
财政年份:1986
-
负责人:WILLIAM R HAZZARD
-
依托单位:
SEX STEROID MODULATION OF HUMAN LIPOPROTEIN METABOLISM
-
批准号:3354335
-
项目类别:
-
资助金额:$8.59万
-
财政年份:1986
-
负责人:WILLIAM R HAZZARD
-
依托单位:
SEX STEROID MODULATION OF HUMAN LIPOPROTEIN METABOLISM
-
批准号:3354332
-
项目类别:
-
资助金额:$15.44万
-
财政年份:1986
-
负责人:WILLIAM R HAZZARD
-
依托单位:
ACADEMIC NURSING HOME
-
批准号:3090864
-
项目类别:
-
资助金额:$2.53万
-
财政年份:1985
-
负责人:WILLIAM R HAZZARD
-
依托单位:
SEX STEROID MODULATION OF HUMAN LIPOPROTEIN METABOLISM
-
批准号:3344849
-
项目类别:
-
资助金额:$18.6万
-
财政年份:1984
-
负责人:WILLIAM R HAZZARD
-
依托单位:
SEX STEROID MODULATION OF HUMAN LIPOPROTEIN METABOLISM
-
批准号:3344850
-
项目类别:
-
资助金额:$8.37万
-
财政年份:1984
-
负责人:WILLIAM R HAZZARD
-
依托单位:
RESEARCH CORE
-
批准号:3960201
-
项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:WILLIAM R HAZZARD
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依托单位:
MODULATION OF HUMAN LIPOPROTEIN METABOLISM BY ESTROGEN
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批准号:3852895
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:WILLIAM R HAZZARD
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依托单位:
RESEARCH CORE
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批准号:3821675
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:WILLIAM R HAZZARD
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依托单位:
RESEARCH CORE
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批准号:4688137
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:WILLIAM R HAZZARD
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依托单位:
海外基金