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Defining the contribution of A-to-I RNA editing by ADAR’s in physiology and disease

Defining the contribution of A-to-I RNA editing by ADAR’s in physiology and disease
定义 ADAR 的 A 到 I RNA 编辑在生理学和疾病中的贡献
批准号:
nhmrc : 1144049
负责人:
A/Pr Carl Walkley
金额:
$49.23万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31

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中文摘要
翻译
我们正在努力了解一个叫做ADAR的蛋白质家族是如何工作的。阿达尔蛋白可以改变细胞RNA的序列。当它们发生突变或在细胞中表达超过正常量时,它们可能会导致人类一系列疾病。我们正试图确定阿达尔蛋白水平或活性的变化如何导致疾病。
英文摘要
We are working on understanding how a family of proteins called ADARs work. ADAR proteins can change the sequence of the cells RNA. When they are mutated or more than normal amounts are expressed in a cell it appears they can cause a range of diseases in humans. We are trying to determine how changes in the level or activity of ADAR proteins may contribute to disease.
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Defining the contribution of A-to-I RNA editing by ADAR’s in physiology and disease
  • 批准号:
    nhmrc : GNT1144049
  • 项目类别:
    Project Grants
  • 资助金额:
    $72.82万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Carl Walkley
  • 依托单位:
Understanding the function of Recql4 in DNA replication and genome maintenance
  • 批准号:
    nhmrc : GNT1126004
  • 项目类别:
    Project Grants
  • 资助金额:
    $69.84万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Carl Walkley
  • 依托单位:
Microenvironmental regulation of blood cells by retinoic acid receptor gamma.
Microenvironmental regulation of blood cells by retinoic acid receptor gamma.
  • 批准号:
    nhmrc : GNT1127551
  • 项目类别:
    Project Grants
  • 资助金额:
    $95.84万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Carl Walkley
  • 依托单位:
海外基金