NEUROHUMORAL CONTROL OF LUNGS AND AIRWAYS

我们提出了一个多学科的研究神经和神经体液调节， 肺和气道，使用细胞生物学，超微结构，生理学， 药理学、免疫学和临床研究。 动物研究将 检查心肺神经和颈动脉体的感觉和运动通路， 它们的中央延髓连接传出神经，反射器官反应 （控制呼吸、气道分泌物、支气管张力）和细胞 反应（调节平滑肌、肥大细胞、粘液腺、离子转运 以及环AMP和GMP）。 Basbaum博士（D-1）将利用形态学技术 与桑普森博士合作， (D-2)，他们也将对这些结构进行神经生理学研究， 如对分离的平滑肌细胞的研究。 纳德尔博士（D-3）将研究 气道上皮损伤对自主控制气道和呼吸的影响。 Drs.柯勒律治和柯勒律治（D-4）将进行神经生理学研究， 心肺感觉神经 麦克唐纳博士和米切尔博士（D-5）将利用 形态学和神经生理学技术来研究颈动脉体调节， 来定位它的中心连接点 Gold博士（D-6）将研究 实验性犬过敏反应中肥大细胞、介质和神经之间的关系。 Drs. Nadel、Davis和Widdicombe（D-7）将研究 粘液分泌和气道中的离子运输。 临床研究的目的是将人类健康的动物研究与 和疾病，并开发特异性和敏感性测试，以早期发现 疾病 Boushey博士（E-1）将研究夸大 对吸入剂的支气管反应。 Gold博士（E-2）将与 为早期发现解剖学疾病而开发的生理测试 问题研究

We propose a multidisciplinary study of neural and neurohumoral regulation of lungs and airways, using techniques of cell biology, ultrastructure, physiology, pharmacology, immunology, and clinical investigation. Animal studies will examine sensory and motor pathways of cardiopulmonary nerves and carotid bodies, their central medullary connections efferent nerves, reflex organ responses (control of breathing, airway secretions, bronchomotor tone), and cellular responses (regulation of smooth muscle, mast cells, mucus glands, ion transport and cyclic AMP and GMP). Dr. Basbaum (D-1) will utilize morphologic techniques to study sensory and motor nerves in airways, collaborating with Dr. Sampson (D-2), who will perform neurophysiological studies of these structures, as well as studies on isolated smooth muscle cells. Dr. Nadel (D-3) will study effects of airway epithelial damage on the autonomic control of airways and breathing. Drs. Coleridge and Coleridge (D-4) will perform neurophysiologic studies on cardiopulmonary sensory nerves. Drs. McDonald and Mitchell (D-5) will utilize morphologic and neurophysiologic techniques to study carotid body regulation and to locate its central connections. Dr. Gold (D-6) will study interactions betweeen mast cells, mediators and nerves in experimental canine anaphylaxis. Drs. Nadel, Davis, and Widdicombe (D-7) will examine autonomic regulation of mucus secretion and ion transport in airways. Clinical investigation will aim to relate the animal studies in humans in health and disease, and to develop specific and sensitive tests for early detection of disease. Dr. Boushey (E-1) will study mechanisms underlying exaggerated bronchial responses to inhaled agents. Dr. Gold (E-2) will correlate physiologic tests developed for early detection of disease with anatomic studies.