CORE--PATHOLOGY

病理学核心提供研究支持和发展， 项目整体规划。 这项工作是由四个 教师，经验丰富，发表在骨髓移植 血液病理学、免疫病理学和传染病。 移植物抗 宿主疾病（GVHD）研究是在涉及皮肤的方案中进行的， 肝脏和肠道研究。抗体的方法和小组正在 评价了新型抗体对GVHD发病机制的研究 新的细胞亚型，用新的共聚焦显微镜方法， 细胞因子和增殖标记物的抗体。 再生障碍性贫血 研究主要涉及改进冷冻方法， 骨髓切片用于浸润的免疫组织学研究 细胞亚型和细胞因子在发病机制中的作用 再生障碍性贫血和阐明正常的免疫解剖学或 骨髓的免疫形态学，这是分析之前必须进行的 的病理状态。 传染性研究涉及到 和应用诊断病毒感染的新方法 新的原位杂交方法和更新的方法， 使用单链探针评估发病机制， 病毒感染的诊断。 病理学也进行组织学检查 对于犬的研究，骨髓增生异常项目，所有的活组织检查， GVHD的诊断、发病机制研究及骨髓检查。 该小组还进行了所有必要的研究尸检， 对接受ATG治疗的患者和骨髓 移植者不能存活。 在其他地方进行的尸检 由工作人员协调和回顾性审查机构 also.

The Pathology Core provides research support and development for the program project grant as a whole. This work is conducted by four faculty, highly experienced and published in marrow transplantation hematopathology, immunopathology, and infectious disease. Graft-versus- host disease (GVHD) studies are carried out in protocols involving skin, liver and gut studies. The methods and panels of antibodies are being evaluated for studies of the pathogenesis of GVHD with novel antibodies to new cellular subtypes, with new confocal microscopic methods, and with antibodies to cytokines and proliferation markers. The aplastic anemia studies are primarily involved with improving the methodology of frozen sections of bone marrow for immunohistological study of infiltrating cellular subtypes and cytokines in the examination of the pathogenesis of aplastic anemia and in elucidating normal immunoanatomy or immunomorphology of bone marrow which necessarily precedes the analysis of the pathologic states. The infectious studies involve the development and application of new methods of diagnosing viral infections with panels of antibodies, new in situ hybridization methods and newer methods of employing single-stranded probes for the evaluation of pathogenesis and diagnosis of viral infections. Pathology also carries out the histology for the canine studies, myelodysplasia project, all of the biopsies for diagnosis and pathogenetic study of GVHD, and the marrow examinations. The group also carries out all the research autopsies necessary for evaluation of the patients receiving ATG therapy and marrow transplantation who do not survive. Autopsies carried out at other institutions are coordinated and reviewed retrospectively by the staff also.