MOLECULAR CELL BIOLOGY IN PEDIATRIC RESEARCH

我们建议建立一个儿童健康研究中心，让年轻的 儿科教员将培养基本的科学研究技能 应用于儿童重要健康问题的研究。中环 该中心的主题将是原理和技术的应用 从分子细胞生物学到研究范围广泛的 儿科临床问题。该中心将由16个临床医生组成 教职员工(10名医学博士、1名医学博士和5名博士)和13名基础科学教员(11名博士、 2名医学博士)，他们都是资金雄厚的老牌调查人员。临床部 教师来自儿科15、医学1和基础科学 微生物学/免疫学7，麻醉学系 (生物物理学/生物物理学2、生物化学1)、细胞生物学2及 生理学/生物物理学1.这个教职人员在 过去在研究和培训方面都有经验。临床教职员工人数众多 在传染病、免疫学和基础科学方面的权重 微生物学，因为他们过去在研究和培训方面的生产力。 尽管我们计划在自然界培养年轻的教职员工 先天性和围产期感染的历史、发病机制和治疗 和其他儿科感染(病毒、细菌、原虫、支原体、 衣原体)和免疫学(发育、一般和免疫遗传学) 不会只集中在这些领域。我们将发展 使用最新技术研究各种器官系统疾病的研究人员 分子细胞生物学正在逼近。通过这种方式，我们中心将支持 以分子细胞为中心的平衡儿科研究 以生物学为纽带。 为了节省研究项目的资金，我们将利用现有的和 共享儿科实验室以及5个已建立的多学科 核心实验室中心。一位来自儿科学院的科学主任 将被任命帮助评估这些实验室并评估他们的 用途和价值，以及提供培训和技术援助 年轻的教职员工。他与项目总监和校长一起 调查员和咨询委员会将监督遴选 研究支助和中心运作的候选人。那里 是一大批来自不同学科的年轻教员，他们可以 中心支持的候选人和我们计划在下一年招募的其他19人 三年了。目前已有12名年轻教职员工(从7名 子专业)参与了该中心提议的研究 教职员工。

We propose to develop a Child Health Research Center to allow young pediatric faculty to develop basic science research skills which will be applied to the study of important health problems in children. The central theme of the Center will be the application of the principals and technics of molecular cell biology to the investigations of a broad range of clinical pediatric problems. The Center will be composed of 16 clinical faculty (10 MD, 1 MD/PhD and 5 PhD) and 13 basic science faculty (11 PhD, 2 MD), all of whom are well funded established investigators. The clinical faculty are drawn from Pediatrics 15, Medicine 1, and the basic science faculty from Microbiology/Immunology 7, Anesthesiology (Biophysiology/Biophysics 2, Biochemistry 1), Cell Biology 2 and Physiology/Biophysics 1. This faculty has had extensive interaction in the past in both research and training. The clinical faculty is heavily weighted in infectious disease and immunology and the basic sciences in microbiology because of their past productivity in research and training. Though we plan to develop young faculty investigators in the natural history, pathogenesis and treatment of congenital and perinatal infections and other pediatric infections (viruses, bacterial, protozoa, mycoplasma, chlamydia) and in immunology (developmental, general and immunogenetics) we will not concentrate exclusively in these areas. We will develop investigators who study various organ systems diseases using state of art molecule cell biology approaches. In this way our Center will support balanced pediatric research using the central theme of Molecular Cell Biology as a link. To conserve funds for research projects we will utilize established and shared pediatric laboratories as well as 5 established multidisciplinary Center Core laboratories. A scientific director from the pediatric faculty will be appointed who will help assess these laboratories and assess their use and value, as well as providing training and technical assistance to the young faculty. He along with the Program Director and Principal Investigator and an Advisory Committee will oversee the selection of candidates for research support and the functioning of the Center. There is a large pool of young faculty from different disciplines who can be candidates for Center support and 19 others we plan to recruit in the next three years. Already 12 of the current young faculty (from 7 subspecialties) are involved in research with the Center's proposed faculty.