CLOZAPINE VS. HALOPERIDOL IN TREATMENT REFRACTORY SCHIZOPHRENIA

氯氮平被称为“非典型抗精神病药物”，因为它并不 诱导催乳素水平的特征性升高，也不 产生“经典”抗精神病药物常见的锥体外系反应。 我们正在进行一项盲法交叉研究，比较临床和 氯氮平AS治疗难治性精神分裂症的生物学反应 与氟哌啶醇相比。 当对足够多的患者进行研究后，我们将进行临床研究， 对每个服用氟哌啶醇的患者进行神经心理学和SPECT研究， 安慰剂和氯氮平。这些结果可能会对潜在的 患者通常具有独特的临床反应性的机制 氯氮平。 到目前为止，已有6名患者完成了治疗方案，这一数字不足以 允许进行数据分析。 一名患者出现严重的癫痫发作。这个人被注意到有 在低谷时，她的脑电(EEG)出现了许多快速活动 药物的剂量。我们正在进行连续脑电检查，看看癫痫风险是否 被预测到了。

Clozapine has been called an "atypical neuroleptic" because it does not induce the characteristic elevations in prolactin levels nor does it produce the extrapyramidal reactions common to "classical" neuroleptics. We are conducting a blinded crossover study comparing clinical and biological response of treatment refractory schizophrenics to clozapine as compared to haloperidol. When enough patients have been studied we will have clinical, neuropsychological, and SPECT studies of each patient on haloperidol, placebo and clozapine. These results may shed some light on the underlying mechanisms for the often unique clinical responsiveness of patients to clozapine. To date six patients have completed the protocol, an insufficient number to permit data analysis. One patient had a grand mal seizure. This person was noted to have developed a lot of fast activity on her electroencephalogram (EEG) at a low dose of the drug. We are obtaining serial EEG's to see if seizure risk can be predicted.