HAEMOPHILUS INFLUENZAE TYPE B REFERENCE LABORATORY

一个H的支持。流感参考实验室， 血清学分析和提供疫苗是 NIAID的脑膜炎疫苗项目。 血清学参考实验室 将作为抗PRP标准化测量的焦点 儿童自然感染H.流感 感染，并在成人和儿童接种候选H。 流感疫苗。 该项目还将提供试剂级PRP， 放射性标记的PRP提供给其他研究者用于分析目的。 没有 此时需要承包商向其他人提供PRP疫苗， 由于几家疫苗制造商现在销售这种产品， 并使其可用。 目前有几个实验室正在研究 PRP疫苗 抗体测定在相同条件下的性能 实验室使用相同的程序和试剂， 不同患者群体和候选疫苗之间的比较。

The support of a H. influenzae reference laboratory for performing serological analyses and supplying vaccine is an integral component of the Meningitis Vaccine Program at the NIAID. The serologic reference laborator would serve as a focal point for the standardized measurement of anti-PRP antibody responses in children with natural disease due to H. influenzae infection, and in adults and children vaccinated with candidate H. influenzae vaccines. The project would also supply reagent grade PRP and radiolabeled PRP to other investigators for assay purposes. There is no need at this time for the contractor to provide PRP vaccine to other investigators since several vaccine manufacturers now market this product and make it available. Several laboratories are currently investigating PRP-based vaccines. The performance of antibody assays in the same laboratory using the same procedures and reagents would allow for comparisons between various patient populations and candidate vaccines.