STRUCTURE AND BIOSYNTHESIS OF PROTEOGLYCANS

该项目的目的是研究化学和物理性质 以及蛋白聚糖在许多组织和细胞系统中的代谢。 目前感兴趣的主题包括：1）蛋白质化学和免疫学， 来自Swarm大鼠软骨肉瘤的蛋白聚糖的核心蛋白; 2） 核心蛋白的生物合成;前体和成熟加工 3）生长因子（胰岛素样生长因子1）的作用 牛器官培养中蛋白多糖代谢的调控 关节软骨; 4）硫酸角质素-蛋白多糖和皮肤素 鸡、猫和人角膜中硫酸盐蛋白聚糖; 5） 硫酸寡糖对骨中蛋白聚糖和唾液蛋白的作用， 软骨肿瘤细胞

The purpose of the project is to study the chemical and physical properties and metabolism of proteoglycans in a number of tissue and cell systems. Topics of present interest include: 1) Protein chemistry and immunology of the core protein of proteoglycans from the Swarm rat chondrosarcoma; 2) Biosynthesis of core protein; precursors and processing to mature proteoglycans; 3) Effects of growth factors (insulin-like growth factor 1) on the regulation of proteoglycan metabolism in organ cultures of bovine articular cartilages; 4) keratan sulfate-proteoglycan and dermatan sulfate-proteoglycan in chick, cat and human cornea; 5) analyses of sulfated oligosaccharides on proteoglycans and sialoproteins in bone and cartilage tumor cells.