ORAL HEALTH AND SALIVARY FUNCTION IN HIV-1 INFECTED PATIENTS

该项目的重点是与HIV-1感染有关的口腔变化。我们 研究了唾液，口腔防御系统的关键部分， 在横断面和纵向研究中观察感染后的变化。在 所有的研究，抗微生物蛋白质乳铁蛋白，溶菌酶，组胺素， HIV-1抗体阳性男性唾液伊加含量升高。的 这些蛋白质，只有溶菌酶继续增加，随着时间的推移。变化 在受刺激的下颌下唾液中最明显。唾液分泌 来自具有唾液腺增大的HIV-1阳性患者， 在干燥综合征中看到的。高海拔地区 唾液伊加、乳铁蛋白和伊加类风湿因子（RF）存在于 HIV-1阳性患者唾液腺肿大较HIV-1 无肿大的阳性患者。然而，病人的唾液 原发性干燥综合征患者唾液伊加水平更高， 乳铁蛋白和伊加RF。最近，一项研究开始调查 与HIV-1感染相关的牙周状况（也见Z 01 DE 00498-01）。初步数据表明，艾滋病毒相关的牙周炎是 不常见，与艾滋病毒相关的牙龈炎更常见。这些 研究希望建立一个合理的理论基础， 在艾滋病中看到的问题。我们还研究了艾滋病的发病率， 老年人，并观察到超过10%的案件在美国。 发生在50岁或以上的患者中。

This project focuses on oral changes associated with HIV-1 infection. We have examined saliva, a critical part of the oral defense system, for changes following infection in cross-sectional and longitudinal studies. In all studies, the antimicrobial proteins lactoferrin, lysozyme, histatins, and salivary IgA were elevated in males positive for HIV-1 antibody. Of these proteins, only lysozyme continued to increase with time. Changes were most dramatic in the stimulated submandibular saliva. Salivary secretions from HIV-1 positive patients with a salivary gland enlargement which mimics that seen in Sjogren's syndrome were analyzed. Higher elevations of salivary IgA, lactoferrin, and IgA rheumatoid factor (RF) were present in HIV-1 positive patients with salivary gland enlargement than in HIV-1 positive patients with no enlargement. However, the saliva from patients with primary Sjogren's syndrome had much higher levels of salivary IgA, lactoferrin, and IgA RF. Recently, a study has started to examine periodontal status associated with HIV-1 infection (also see Z01 DE 00498-01). Preliminary data suggest that HIV-associated periodontitis is not frequently seen, and HIV-associated gingivitis is more common. These studies hope to establish a logical rationale for treatment of the oral problems seen in AIDS. We have also examined the incidence of AIDS among older persons, and observed that greater than 10% of cases in the U.S. occur in patients aged 50 years or older.