PILOT--EFFECT OF GH ON NITROGEN RETENTION DURING INTRADIALYTIC HYPERALIMENTATION

长期维持性血液透析患者的营养状况 多项研究表明， 预测随后的发病率和死亡率。 差的患者 透析时的营养摄入具有负氮平衡， 心血管事件和严重 感染并发症 这些高风险患者中的大量人群 在任何慢性透析人群中都很容易识别。 在这项研究中，我们提出了两种方法来研究营养， 在这个患者群体中的补充。 一种是使用肠外氨基 酸和葡萄糖输注，另一种是 用外源性生长激素补充。 完成双臂 这项研究的结果可能会产生有关人类能力的新信息 来逆转分解代谢过程。 制定一项 导致正氮平衡有效治疗方式可 对患者的发病率和死亡率有重大影响。 动物研究表明，这是一种潜在的治疗形式。 的 增加合成代谢（或甚至减少分解代谢）作用的证明 在透析患者人群中的生长激素可能会产生巨大的 对透析患者发病率和生存率的影响，特别是对于那些 都是营养摄入不足的普通患者。

The nutritional status of patients on chronic maintenance hemodialysis has now been shown in multiple studies to be one of the major factors predictive of subsequent morbidity and mortality. Patients with poor nutrition intake on dialysis have a negative nitrogen balance and have been shown to be at high risk for cardiovascular events and for serious infectious complications. A large population of these high risk patients are readily identifiable in any chronic dialysis population. In this study, we propose to investigate two approaches to nutritional supplementation in this patient population. One is to use parenteral amino acids and glucose infusions alone during dialysis and the other is to supplement this with exogenous growth hormone. The completion of both arms of this study will potentially yield new information about the ability of dialysis patients to reverse a catabolic process. The development of an effective treatment modality that results in positive nitrogen balance can have a major impact on patient morbidity and mortality. Animal studies suggest that this is a potential form of therapy. The demonstration of increased anabolic (or even decreased catabolic) effects of growth hormone in the dialysis patient population could have enormous impact on dialysis patient morbidity and survival, particularly for those all to common patients with poor nutritional intake.