SPECIALIZED CENTER OF RESEARCH IN ISCHEMIC HEART DISEASE

该计划包括实验室和临床研究计划，旨在 阐明心脏病发作（急性心肌梗死）的机制 和人体和实验模型中的局部缺血（冠状动脉血流不足）， 目的是为了更好地了解自然历史和 冠心病患者内科和外科治疗的效果。 采用的方法包括生化研究，急性实验， 各种动物制剂，对缺血和梗塞的研究及其 在长期使用仪器、未麻醉的动物和亚人动物中的治疗 灵长类动物和缺血性心脏病患者的研究。 临床 项目将特别关注心脏病后的预测和降低风险 发作，使用心电向量图和放射性核素方法进行运动试验，新 放射性核素技术用于研究局部功能和灌注， 血管扩张剂在心力衰竭中的作用。 实验室项目关注 心绞痛动物模型及其治疗，运动对心绞痛的影响， 冠状动脉侧支循环的发展，线粒体酶的使用。 两者 临床和实验室研究项目将带来血液动力学和 放射学方法，核技术，超声心动图，植入式超声 设备，遥测，组织学，基本的生化测量，以及新的 统计技术对解决这些问题的影响。

This program encompasses a laboratory and clinical research program aimed at clarifying the mechanisms involved in heart attack (acute myocardial infarction) and ischemia (inadequate coronary blood flow) in man and experimental models, with the goal of providing a better understanding of the natural history and the effects of medical and surgical therapy in patients with coronary heart disease. The approaches employed include biochemical studies, acute experiments in a variety of animal preparations, studies on ischemia and infarction and their treatment in chronically instrumented, unanesthetized animals and in subhuman primates, and investigations in patients with ischemic heart disease. Clinical projects will focus particularly on prediction and reduction of risk after heart attack, exercise testing using vectorcardiographic and radionuclide methods, new radionuclide techniques for studying regional function and perfusion, and the effects of vasodilators in heart failure. Laboratory projects are concerned with animal models for angina pectoris and its treatment, effects of exercise on coronary collateral development, use of mitochrondrial enzymes. Both the clinical and laboratory research programs will bring hemodynamic and radiographic methods, nuclear techniques, echocardiography, implanted ultrasonic devices, telemetry, histology, basic biochemical measurements, and new statistical techniques to bear on the solution of these problems.