ANTI-HIV POTENTIAL OF PENTOSAN POLYSULFATE

聚硫酸戊聚糖(PPS)是一种半合成聚阴离子，一直处于 在这里进行了多年的调查，作为预防治疗 偏头痛和丛集性头痛。因为我们观察到增加了 治疗患者的循环T细胞，因为报道了 另一种硫化聚阴离子，葡聚糖硫酸酯与AZT的协同作用，我们有 进行了体外实验，以评估其治疗潜力 这种药。 利用人类外周血单个核细胞，我们已经能够 PPS与阿奇杜韦(AZT)在抑制PPS中的协同作用 HIV-1的增长。我们还观察到PPS和葡聚糖硫酸盐单独在 浓度低于1.0ug/ml时，可刺激病毒复制。 后一项发现特别重要，因为有报道称 硫酸葡聚糖的“地下市场”。这表明，患有 如果他们服用聚阴离子，艾滋病实际上可能会使他们的病情恶化 比如葡聚糖。 另一方面，发现AZT和PPS之间有很强的协同作用 鼓励仔细设计临床研究以评估这一点 作为艾滋病治疗的辅助物质的物质可能允许 有效低剂量的AZT。

Pentosan polysulfate (PPS), a semi-synthetic polyanion, has been under investigation here for a number of years as a prophylactic treatment for migraine and cluster headache. Since we observed an increase of circulating T-cells in treated patients and because of the reported synergism of another sulfated polyanion, dextran sulfate, with AZT, we have performed in-vitro experiments to evaluate the therapeutic potential of this drug. Using human peripheral blood mononuclear cells we have been able to demonstrate synergism of PPS with aziduvine (AZT) in the suppression of HIV-1 growth. We also observed that PPS and dextran sulfate alone in concentrations less than 1.Omug/ml stimulated viral replication. This latter finding is particularly important because of the reported "underground market" for dextran sulfate. It suggests that persons with AIDS could actually worsen their condition if they were to take polyanions such as dextran. On the other hand, the finding of a powerful synergism between AZT and PPS gives encouragement to careful design of clinical research to evaluate this substance as an adjunct to the treatment of AIDS that might permit effective lower dosing of AZT.