MOLECULAR AND IMMUNE INTERDICTION OF AIDS

迄今为止，治疗性干预措施未能预防或控制 感染人类免疫缺陷病毒（HIV）。 发展 新的战略需要多方面的努力，包括 在广泛的医学科学领域熟练的个人。 的 AECOM艾滋病研究中心（CFAR）的主要力量在于 在其高度互动的研究历史上， 尤其是艾滋病。 AECoM的专家研究人员专注于 艾滋病毒感染及其对胎儿影响的研究 婴儿和孕妇，我们的调查导致了 识别具有异常良性病程的患者， 可能的免疫监视机制， 经胎盘传播艾滋病毒。 这些发现是 拟开展的艾滋病分子和免疫阻断研究。 在临床研究和基础研究的共同努力下， 科学，我们将集中在几个领域：（1）识别和 开发优化的人和鼠中和抗体; (2)艾滋病疫苗的抗独特型和分枝杆菌载体;（3） 通过细胞免疫干扰HIV复制周期 HIV表达的调控机制;（4）细胞和分子生物学 HIV在神经系统中复制的分析 细胞系、器官型培养物和胎儿脑组织。 儿童和成人;（5）分子表征 艾滋病中的弓形虫病 跨学科合作将 通过几个共享设施来促进：（1）翻新 有足够的空间进行集中的行政和协调 临床和基础研究中心（Mazer）。 该设施还将 设有一个集中数据管理和艾滋病专用会议 （2）发展共用研究核心设施 包括：流式细胞术;杂交设备;寡核苷酸和 （3）资金分配用于两个新的 调查员，新举措和危机支持，以加强 新的想法，并确保研究工作的连续性。 恒虚警 参与AECOM的调查人员通过以下方式进行高度互动： 部门关系，艾滋病研究计划的成员资格 在癌症中心。 其中包括国家认可的 临床研究人员和科学家，其中三人是 国家科学院

Therapeutic interventions have so far failed to prevent or control infection with the human immunodeficiency virus (HIV). Development of novel strategies requires a multidisiplinary effort including individuals skilled in a broad range of the medical sciences. The major strength of the AECOM Center for AIDS Research (CFAR) rests up on its history of highly interactive research in general and in AIDS in particular. Expert researchers ar AECoM have focused for years on the study of HIv infection in and its effect on fetuses infants and pregnant women our investigations have lead to the identification of patients with unusually benign disease course and of the possible mechanisms of immune surveillance interfering with transplacental transmission of HIV. These findings are the key for the proposed research on molecular and immune interdiction of AIDS. In a concerted effort of clinical investigations and basic sciences, we will focus on several areas: (1) Identification and development of optimized human and murine neutralizing antibodies; (2) Antiidiotypes and mycobacterial vectors for AIDS vaccines; (3) Interference with the HIv replication cycle through cellular regulatory mechanisms of HIv expression; (4) Cellular and molecular analysis of HIv replication in the nervous system utilizing cell lines, organotypic cultures and brain tissues from fetuses. children and adults; (5) Molecular characterization of Toxoplasmosis in AIDs. The interdisciplinary collaboration will be fostered through several shared facilities: (1) The renovation of ample space for a centralized administrative and coordinative clinical and basic research core (Mazer). This facility will also house a centralized data management and AIDS-designated conference rooms; (2) Development of shared research core facilities including: Flow cytometry; Hybridoma facility; oligonucleotide and peptide synthesizing facility; (3) Funds are allocated for two new investigators, new initiatives and for crisis support to enhance novel ideas and ensure continuity of research efforts. The CFAR participating AECOM investigators are highly interactive through departmental affiliations, membership in the AIDS Research program and in the Cancer Center. They include nationally recognized clinical researchers and scientists, three of whom are members of the National Academy of Science.