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EXPANSION OF THE PEDIATRIC AIDS CLINICAL TRIAL GROUP

扩大儿科艾滋病临床试验组

基本信息

批准号：
3547254
负责人：
Arye Rubenstein
金额：
$ 67.99万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-09-30 至 1994-07-31
项目状态：
已结题

项目摘要

This is an already existing and functional interdisciplinary multicentered consortium of experts dedicated to health care, clinical as well as basic research related to HIV infection in children (PAIDS) and pregnant women. Members of this Bronx based network include health care professionals, biostatisticians, pharmacologists, and scientists in the filed of pediatrics, immunology, infectious diseases, microbiology, molecular biology and genetics. The network effectively covers the Bronx the largest epicenter of pediatrics AIDS nationwide. It is the first and largest PAIDS center in the USA> The projected new pediatric HIV infected newborns in the geographic catchment area of the consortium is also the largest, with over 4% of all cord bloods being HIV antibody positive. Members of the group have gained experience in adult ATEU trials and in pediatric treatments designed at AECOM. The development of a pediatric ACTG will complement our existing efforts by enabling us to include adult and pediatric members of the same HIV infected family in therapeutic trials. Such an AIDS Family oriented approach has improved enrollment and longterm compliance. The Albert Einstein College of Medicine PAIDS Cooperative Treatment Group will interact with the NIH ACTGs to foster research aimed at the design of novel therapeutic approaches in the areas of immune reconstitution, anti-HIV agents and treatment trials for HIV related diseases.

这是一个已经存在的和功能的跨学科致力于医疗保健、临床和以及与儿童艾滋病毒感染有关的基础研究，孕妇这个以布朗克斯为基础的网络的成员包括医疗保健专业人员、生物统计学家、药理学家和科学家，儿科学，免疫学，传染病，微生物学，分子生物学和遗传学。这个网络有效地覆盖了布朗克斯全国最大的儿科艾滋病中心它是第一个，美国最大的PAIDS中心>预计新的儿科艾滋病毒感染者新生儿在该联盟的地理集水区也是最大的，超过4%的脐带血是艾滋病毒抗体阳性。该小组的成员在成人ATEU试验中获得了经验， AECOM设计的儿科治疗。儿科学的发展 ACTG将补充我们现有的努力，使我们能够包括成人和同一个HIV感染家庭的儿科成员进行治疗，审判这种面向艾滋病家庭的方法提高了入学率，长期遵守。阿尔伯特·爱因斯坦医学院PAIDS合作治疗组将与NIH ACTG互动，以促进旨在设计的研究免疫重建领域的新治疗方法，抗HIV药物和HIV相关疾病的治疗试验。