Dendritic cell function, migration and modulation in a murine model of inflammatory arthritis

类风湿性关节炎(RA)是一种影响关节和其他组织的衰弱疾病。虽然它通常可以通过药物控制，但完全缓解的治疗是罕见的。树突状细胞是免疫系统的教育者。通过向T细胞展示抗原，它们传达了免疫系统对外来生物、肿瘤和自身的反应。因此，沟通障碍可能导致慢性炎症、肿瘤生长或自身免疫性疾病，如类风湿关节炎。在这项建议中，我们专注于树突状细胞在类风湿性关节炎小鼠模型中的作用，并探索使用树突状细胞来关闭疾病的方法，如果成功，可能会在人类身上转化为诱导缓解。

Rheumatoid arthritis (RA) is a debilitating disease that affects the joints and other tissues. While it can often be controlled with drugs, complete remission off treatment is rare. Dendritic cells are the educators of the immune system. By displaying antigen to T cells they communicate the response that the immune system should make to foreign organisms, tumors and to self. Therefore, a communication failure may result in chronic inflammation, tumor growth or autoimmune disease, such as RA. In this proposal, we focus on the role of dendritic cells in a mouse model of RA and explore ways of using dendritic cells to turn off disease, that if successful may translate in humans to induction of remission.