STRUCTURE AND BIOSYNTHESIS OF PROTEOGLYCANS

该项目的目的是研究化学和物理 许多组织中蛋白聚糖的性质和生物合成 和细胞系统。 目前感兴趣的主题包括：1）蛋白质 蛋白聚糖核心蛋白的化学和免疫学 Swarm大鼠软骨肉瘤; 2）核心蛋白生物合成 前体和成熟蛋白聚糖的加工; 3） 细菌内毒素（脂多糖）、白细胞介素-l和 生长因子（胰岛素样生长因子和转化生长因子 β因子）对器官蛋白多糖代谢的调节 牛关节软骨培养物; 4）调节 器官培养中透明质酸合成和催化活性 牛关节软骨; 5）硫酸蛋白多糖和皮肤素 鸡、猫和人角膜中硫酸盐蛋白聚糖。

The purpose of the project is to study the chemical and physical properties and biosynthesis of proteoglycans in a number of tissue and cell systems. Topics of present interest include: 1) Protein chemistry and immunology of the core protein of proteoglycans from the Swarm rat chondrosarcoma; 2) Biosynthesis of core protein precursors and processing to mature proteoglycans; 3) Effects of bacterial endotoxins (lipopolysaccharides), interleukin-l and growth factors (insulin-like growth factors and transforming growth factor beta) on the regulation of proteoglycan metabolism in organ cultures of bovine articular cartilages; 4) The regulation of hyaluronic acid synthesis and catabolism in organ cultures of bovine articular cartilage; 5) sulfate-proteoglycan and dermatan sulfate-proteoglycan in chick, cat, and human cornea.