MUSCLE CAPILLARY BASEMENT MEMBRANE THICKNESS PRIOR TO ONSET OF DIABETES

一些代谢和形态学变化被认为是 在糖尿病发病之前，包括模式的变化， 胰岛素分泌量和厚度的变化 毛细血管基底膜。 这项研究将确定， 肌毛细血管基底膜增厚是一个特征 糖尿病前期状态，如果是这样，增厚是否是 在糖尿病发病前多年就存在，因此可以 被认为是糖尿病前期的标志物，或者它是否会发展成糖尿病前期， 与发病前发生的代谢异常无关 糖尿病性高血糖 父母都患有糖尿病的皮马印第安人， 糖尿病患者均未接受口服和静脉注射 葡萄糖耐量试验，以及来自 毛细管厚度的定量测定 糖尿病患者基底膜随年龄增长的变化 与没有父母的人相比。 结果将有助于 确定毛细血管水平的血管病变是否 在高血糖发生之前出现。

Several metabolic and morphologic changes have been claimed to precede the onset of diabetes, including changes in the pattern and quantity of insulin secretion and alteration in the thickness of capillary basement membranes. This study will determine if muscle capillary basement membrane thickening is a characteristic of the prediabetic state, and if so whether the thickening is present many years before the onset of diabetes, and therefore can be considered a prediabetic marker, or whether it develops pari passu with metabolic abnormalities that occur prior to the onset of diabetic hyperglycemia. Pima Indians with two diabetic parents, and with neither patient diabetic received oral and intravenous glucose tolerance tests, and a biopsy of the quadriceps muscle from which quantitative determinations of the thickness of the capillary basement membrane with increasing age in those with diabetic parents compared to those without. The results will help to determine if vascular lesions at the level of the capillary are present before hyperglycemia develops.