GC-MS ANALYSIS OF PCDF BLOOD LEVELS IN CHILDREN EXPOSED IN VITRO

已经发生了两起多氯化人类中毒事件 联苯(FCB)及其热击穿产物；第一， 1968年在日本，1979年在台湾第二次。因为多氯联苯是 这是一个世界性的污染问题，人们对这些事件进行了研究 小心翼翼，因为他们提供了唯一的机会 在室外直接观察多氯联苯对人体的毒性 工作场所。评价这些物质的实验室方法 1968年的疫情相对来说并不复杂； 自那以后，分析方法取得了巨大的进步。与 台湾科学家，NIEHS流行病学分会，有 有机会检查100多名在宫内的儿童 1979年中毒事件发生的时间或之后。这些孩子 继续受到影响，因为化学物质不能被排泄出来 从母亲的身体里。 在一项合作努力中，质谱学工作组将 分析大约120份血清样本中的四、五和 六氯二苯并呋喃，以百万分之几的水平。我们有 目前验证了提取程序并分析了 样品将于1989财年开始。

There have been two outbreaks of human poisoning by polychlorinated biphenyls (FCBs) and their thermal breakdown products; the first, in Japan in 1968, the second in Taiwan in 1979. Because PCBs are a world wide pollution problem, these episodes have been studied carefully, since they have presented the only opportunity to observe directly the toxicity of PCBs in human beings outside the workplace. Laboratory methods for the evaluation of these outbreaks were relatively unsophisticated in 1968; there has been great progress in analytical methods since. In collaboration with Taiwanese scientists, the Epidemiology Branch, NIEHS, had the opportunity to examine over 100 children who had been in utero at the time of the 1979 poisoning or afterward. These children continued to be affected, since the chemicals cannot be excreted from the mother's body. In a collaborative effort, the mass spectrometry workgroup will analyze approximately 120 serum samples for tetra-, penta- and hexachlorodibenzofurans at the part per trillion level. We have currently validated the extraction procedure and analysis of the samples will commence in FY 1989.