SYNCHROTRON X-RAY MICROPROBE FACILITY

布鲁克海文同步加速器X射线微探头研究 资源使用由美国国家航空航天局生产的高能X射线 用于灵敏痕量元素的同步辐射光源 分析和成像各种类型的生物结构。这个 NSLs是一种独特的明亮的x射线源，因此可以作为 目前无与伦比的资源基础 任何其他地方。该资源的目标是将 来自生命科学和物理科学的科学家在一个 推动同步加速器潜力的多学科努力 用于元素x射线荧光测量的辐射(1) 在敏感性、空间和空间方面的最大限度 分辨率、所检查元素的化学形态和(2) 进行广泛的生物学研究计划以开发 技术开发计划的结果。其他 布鲁克黑文核设施被用来补充 NSLS上的光子光束的特征，以便提供其他 必要时采用核分析技术。完整的 设备填补了高分辨率电子显微镜之间的空白 和批量分析技术。同步加速器的组合 随着计算机断层扫描技术的发展， 层析成像进入了许多新的研究领域。此资源使用 来自弯曲磁铁的辐射，以提供过滤的白光或 单色辐射。增加了聚焦镜 该系统将在目标处提供更高的流量，并增加 测定的灵敏度。两种不同类型的镜子 计划是：一个简单的1：1柱面镜子和一个8：1椭球面 在两个维度聚焦的镜子。目标是获得 检测灵敏度低于50-100 ppb(按重量计) 20-磁矩。该资源目前可以与 光点大小为25个磁矩，检测灵敏度 铁周围的元素含量约为200 ppb。最初的生物学 研究工作的目的是研究痕迹的几个方面 元素生物学与毒理学：(1)微量元素在中国的定位 肝小叶，(2)微量元素相互作用，(3)痕量 啮齿动物小脑的元素分析，(4)鼠脑的体视学分析 微探针数据，以及(5)胫骨中铅的体内分析。一个 相关分析和研究领域的协作项目数量 生物领域正在与来自其他国家的科学家一起取得进展 机构。运行服务程序以确保 所有符合条件和有兴趣的人都可以自由使用资源 科学家。该资源的新功能通过以下方式公布 定期举办一系列讲习班、座谈会和研讨会 由资源工作人员提供。

The Brookhaven Synchrotron X-Ray Microprobe Research Resource uses high-energy x-rays produced by the National Synchrotron Light Source (NSLS) for sensitive trace-element analysis and imaging in various types of biological structures. The NSLS is a uniquely bright source of x-rays and thereby serves as the foundation of the Resources which is presently unsurpassed at any other location. The aim of the Resource is to combine scientists from the life and physical sciences in a multidisciplinary effort to push the potentialities of synchrotron radiation for elemental x-ray fluorescence measurements to (1) the furthest possible limits in terms of sensitivity, spatial resolutions, and chemical form of the elements examined and (2) to carry on an extensive biological research program to exploit the results of the technical development program. Other Brookhaven nuclear facilities are used to complement the features of the photon beams at the NSLS so as to provide other nuclear analytical techniques when necessary. The complete facility fills the gap between high resolution electron microscopy and bulk analysis techniques. The combination of the synchrotron with computed tomography techniques extends the possibilities of tomography into many new research regions. This Resource uses radiation from a bending magnet to provide filtered white light or monochromatic radiation. The addition of focussing mirrors to the system will give higher fluxes at the target and increase the sensitivity of the determinations. Two different types of mirrors are planned: a simple 1:1 cylindrical mirror and an 8:1 ellipsoidal mirror which focusses in two dimensions. The goal is to obtain detection sensitivities less than 50-100 ppb (by weight) in a 10- to 20-magnetic moment. The Resource presently can be used with a spot size of 25 magnetic moment, and a detection sensitivity around 200 ppb for elements around iron. The initial biological research effort is aimed at studying several aspects of trace element biology and toxicology: (1) trace element localization in the hepatic lobule, (2) trace element interactions, (3) trace element analysis of rodent cerebellium, (4) sterological analysis of microprobe data, and (5) in-vivo analysis of lead in the tibia. A number of collaborative projects in related analytical and biological fields are in progress with scientists from other institutions. A service program is operated to make sure that the Resource can be used freely by all qualified and interested scientists. The new features of the Resource are made known by a regular series of workshops and symposia and seminars presented by the Resource staff.