DETERMINING THE ROLE OF ER STRESS INDUCED APOPTOSIS IN THYMIC NEGATIVE SELECTION

细胞凋亡是一种进化保守的机制，用于杀死不再需要的、受损的、被病原体感染的或危险的不需要的细胞。细胞凋亡缺陷可引起许多疾病。例如，细胞的异常存活会导致癌症或自身免疫性疾病。Bim是一种诱导细胞凋亡的蛋白质，是对抗癌症和自身免疫性疾病的屏障。这项工作旨在了解Bim如何作为自身免疫发展的障碍。

Apoptosis is an evolutionarily conserved mechanism for killing unwanted cells that are no longer needed, damaged, infected with pathogens or dangerous. Defects in apoptosis can cause a number of diseases. For example, abnormal survival of cells can cause cancer or autoimmune disease. Bim is a protein that induces apoptosis and act as a barrier against cancer and autoimmune diseases. This work is aimed at understanding how Bim acts as a barrier against the development of autoimmunity.