PURCHASE OF AN EPR/ENDOR SPECTROMETER

普林斯顿大学化学系将 购买电子顺磁共振/电子核 BRS支持的双共振光谱仪 共享仪表计划。 该工具需要 美国国立卫生研究院化学和生物系成员 资助以下领域的研究： 1. 蛋白质对质子和电子转移的控制 2. 细胞色素P450作用机制的分子探针 3. 细胞骨架膜相互作用 4. α-酮酸双加氧酶的机理研究 5. 稳定的前列环素治疗血管疾病 6. 天然抗癌药物的合成 7. 天然产物合成 8. 生物学中的金属中心：血红素、铁硫和铜 蛋白 9. 血红素蛋白结构与动力学 所提出的EPR谱仪是需要取代老化的 1968年购买的光谱仪，现已过时 部分无功能。 ENDOR配件将扩大 用户组的能力进入一个新的领域， 顺磁材料的高分辨率研究。 这将是 对化学结构的研究特别有价值， 远距离原子核和磁各向异性材料的动力学。 通过这些研究，该仪器将用于 培养下一代普林斯顿学生 生物医学领域。

The Department of Chemistry at Princeton University will purchase an Electron Paramagnetic Resonance/Electron-Nuclear Double Resonance Spectrometer with support from the BRS Shared Instrumentation Program. The instrument is needed by members of the Chemistry and Biology Departments for NIH funded research in the following areas: 1. Protein Control of Proton and Electron Transfer 2. Molecular Probes of the Mechanism of Cytochrome P450 3. Cytoskeleton Membrane Interactions 4. Mechanistic Studies of alpha-Ketoacid Dioxygenasese 5. Stabilized Prostacyclins to Treat Vascular Diseases 6. Synthesis of Natural Anticancer Agents 7. Natural Product Synthesis 8. Metal Centers in Biology: Hemes, Iron-Sulfur and Copper Proteins 9. Hemeprotein Structure and Dynamics The proposed EPR spectrometer is needed to replace an aging spectrometer that was purchased in 1968 and is now out of date and partially non-functional. The ENDOR accessory will expand the capabilities of the user group into a new area by permitting high resolution studies of paramagnetic materials. This will be especially valuable for studies of the chemical structure and dynamics of distant nuclei and magnetically anisotropic materials. Through these research studies this instrument will be used in training the next generation of Princeton students entering biomedical fields.