Biomarkers of clinical transplantation tolerance

肾移植受者需要终生服用抑制免疫系统（免疫抑制）的药物。这些药物有严重的副作用，而我们目前没有。我有办法知道每个病人需要多少治疗。我们最近定义了一系列测试，可以让我们确定哪些肾移植受者在解除免疫抑制后不会排斥他们的移植物。这些都是非常初步的结果。我们需要进行几项研究来证实它们。因此，我们建议在新的患者组中重复这项研究。如果得到验证，我们的试验可用于安全地减少或消除肾移植受者的免疫抑制。我需要它。

Kidney transplant recipients need to be treated with drugs that hold down the immune system (immunosuppression) for life. These drugs have important side effects and we currently don?t have means to know how much treatment each patient needs.We have recently defined a series of tests that may allow us to identify which kidney transplant recipients do not reject their grafts when taken off immunosuppression. These are very preliminary results. We need to perform several studies to confirm them. Thus, we are proposing to repeat the study in new groups of patients. If validated our tests could be used to safely minimise or remove immunosuppression in those kidney transplant recipients that don?t need it.