DPFS Resource request (King s College London)

应用基础医学研究成果改善患者健康是现代医学的主要目标。为了做到这一点，至关重要的是，我们必须确定最好的科学想法，这些想法可以导致开发新的治疗方法，改进诊断疾病和预测不同治疗方法的有效性的方法。将这些基本发现开发或转化为应用(翻译研究)是MRC？S发展之路资助计划(DPFS)的目标。伦敦S国王学院致力于翻译研究，并在人员和设施方面投入了大量资金，以促进和支持我们在这方面的活动。鉴于S国王学院对翻译研究的浓厚兴趣，我们预计我们的科学家将向该计划提交大量申请，我们将有大量的资助项目正在运行。DPFS项目有内置的里程碑，可以用来衡量研究的进展，以及如果没有实现预期的进展，项目可以停止的通过/不进行点。大多数学术科学家在这种基于里程碑的翻译项目中经验有限。我们正在请求为移交投资组合支持提供支持资源，以招聘一名投资组合支持人员来管理S国王的应用程序和资助的项目。金？S的项目组合支持人员将能够在申请DPF拨款之前与科学家互动，以确保提案具有强大的翻译潜力，具有现实的里程碑和决策点。当地工作人员将监督S国王项目，并协助科学家进行项目管理。这种监督将允许密切监测每个项目的进展情况，以确保项目保持在正轨上，并确保任何潜在问题都能在早期阶段被发现和补救。部署基于S国王的投资组合支持人员将使S国王和MRC都受益。金？S的投资组合支持人员将帮助申请者起草他们的翻译建议，从而提高申请的质量和相关性。因此，投资组合支持人员将通过增加高质量DPF项目的数量并最大限度地增加它们实现目标或在适当的早期阶段被终止的可能性，使King？S和MRC都受益。下放投资组合也将减轻MRC总部监督S国王项目的负担。

The application of basic medical research results to improve the health of patients is a main goal of modern medical science. In order to do this, it is essential that we identify the best scientific ideas that can lead to the development of novel therapies and improved ways to diagnose diseases and predict the effectiveness of different treatments. The development or translation of these basic discoveries into applications (translational research) is the aim of the MRC?s Developmental Pathway Funding Scheme (DPFS). King?s College London is committed to translational research and has invested heavily in both staff and facilities to promote and support our activities in this area. Given the strong interest in translational research at King?s, we expect that our scientists will submit a large number of applications to the scheme and that we will have a significant number of funded projects running. The DPFS projects have in-built milestones, which can be used to measure progress of the research, and Go/No Go points where the project can be stopped if the expected progress is not achieved. Most academic scientists have limited experience in such translational, milestone based projects. We are requesting underpinning resources for devolved portfolio support to recruit a member of portfolio support staff to manage the King?s applications and funded projects. A member of portfolio support staff based at King?s will be able to interact with the scientists prior to applying for DPFS grants to ensure that proposals have a strong translational potential with realistic milestones and decisions points. Locally based staff will oversee the King?s projects and assist the scientists with project management. This oversight will allow the progress of each project to be closely monitored to ensure that projects remain on-track and that any potential problems can be identified and remedied at an early stage. The deployment of King?s based portfolio support staff will benefit both King?s and the MRC. King?s based portfolio support staff will assist applicants in the drafting of their translational proposals and so improve the quality and relevance of applications. Portfolio support staff will therefore benefit both King?s and the MRC by increasing the number of high quality DPFS projects and by maximizing the probability that they achieve their goals or are terminated at an appropriate early stage. A devolved portfolio will also reduce the burden on MRC Head Office of overseeing projects at King?s.