200 MHZ NUCLEAR MAGNETIC RESONANCE SPECTROMETER

核磁系统要实现的长期目标 共振（NMR）光谱仪被美国收购 牙科协会健康基金会 中心分为两组： 宽带液体探针，以及宽带液体探针所满足的那些目标。 固体CP/MAS探头。 液体探头工作范围从常规的 PRC粘合剂有机组分的1H和13 C测定 人类患者临床试验的详细机制 对实验室和实验室的有机成分进行了研究， 商业系统。 较新的含氟系统， 磷也可以通过19 F和31 p NMR来研究。 辐射对DNA和蛋白质的损伤将通过1H， 13 C、31 P、2 H、17 O和15 N NMR光谱 从细胞组织中提取的化合物。 测定 各种正磷酸根离子在水溶液中的分布， 非水溶液作为pH的函数将利用31 P NMR 能力的 聚合产物的~（13）C、~（19）F、~（31）P核磁共振研究 PRC和商业粘合剂系统将包括一个主要用途 宽带固体探测器 牙齿中磷的研究 将利用固体探针31 P的能力。 固体探测器，通过 29 Si观察，将表征复合材料的玻璃嵌件 邻面和咬合面的修复。 小说 复合材料聚合的引发机理， 将通过溶液和固体观察粘合剂系统 阶段。 性能标准和检测水平 将确定固体中的结构差异。 这次核磁共振光谱仪采集的健康相关性在于 主要用于牙齿缺损的预防和修复领域。 通过应用有机成分和复合物的溶液 结合到牙本质和牙釉质表面的材料， “钻孔”量（以及对麻醉剂的需求）将减少 因为不再有必要削减重要的 支持性牙本质，使底切和机械锁定 填充材料到位。 通过改善粘合剂结合 治疗，将成为可能，以提供保护涂层， 暴露的根面，其中有牙龈退缩 由于年龄或疾病。

The long-term objectives to be fulfilled by the Nuclear Magnetic Resonance (NMR) Spectrometer acquisition by the American Dental Association Health Foundation Paffenbarger Research Center are divided into two groups: those objectives met by a broadband liquids probe, and those objectives met by a broadband solids CP/MAS probe. Liquids probe work will range from routine 1H and 13C assays of organic components of the PRC adhesive protocol for human patient clinical trials to detailed mechanistic studies on the organic components of experimental and commercial systems. Newer systems containing fluorine and phosphorous can be studied by 19F and 31p NMR as well. Radiation damage to DNA and proteins will be studied by 1H, 13C, 31P, 2H, 17O and 15N NMR spectroscopy on labelled compounds extracted from cellular tissues. Determination of the distribution of various orthophosphate ions in aqueous and nonaqueous solution as a function of pH will utilize 31P NMR capabilities. The 13C, 19F, 31P NMR study of the polymerized product of the PRC and commercial adhesive systems will comprise a major use of the broadband solids probe. The study of phosphorous in teeth will utilize the solids probe 31P capability. The solids probe, via 29Si observation, will characterize glass inserts for composite restorations of interproximal and occlusal surfaces. Novel initiation mechanisms for the polymerization of composite and adhesive systems will be observed via both solution and solid phases. Performance standards and levels of detection of structural differences in solids will be determined. The health relatedness of this NMR spectrometer acquisition lies primarily in the field of prevention and repair of tooth defects. By applying solutions of organic components and composite materials which bond to the surface of dentin and enamel the amount of "drilling" (and need for anesthetics) will be reduced because there will no longer be the necessity to cut away vital supportive dentin to make undercuts and mechanically lock the filling material into place. By improving adhesive bonding treatments, it will become possible to provide protective coatings of exposed root surfaces where there has been gingival recession due to age or disease.