London Neurodegenerative Diseases Brain Bank (LNDBB) : a national resource for the neuroscience research community

脑库收集患有神经退行性疾病的人的死后脑组织，如痴呆症和运动神经元病。只要有可能，以前的临床表现、神经心理测试和神经成像的数据也被收集起来。脑组织由神经病理学家检查，并根据国际公认的标准诊断疾病。各种固定状态的脑组织样本，如冰冻和福尔马林固定，然后与脊髓组织和脑脊液一起提供给神经科学研究中心，如果有的话。该项目的目的是提供经过临床研究和病理验证的脑组织，以促进和促进神经退行性疾病的国际竞争研究。脑库的目标是履行有关脑组织银行的国际建议和指南。因此，这涉及有系统和有重点地收集具有良好特点的尸检材料，并随后将其分发给区域和国家的研究小组。这必然会支撑高质量和同行评议的研究。以下是脑库的主要职能摘要：1.通过向研究界提供临床和神经病理特征良好的脑组织，促进对神经退行性疾病和神经疾病的根本原因的了解和促进研究。2.通过伦理上批准的队列研究和临时捐赠的知情同意方案，促进脑捐赠。根据国家和国际最佳方案为脑捐献者亲属提供病理诊断。协调为临床、生化、分子病理学、遗传和转录研究项目处理和分发保存完好的脑组织，并保持开放的政策，不带偏见地回应请求者。以确保？捐赠者的关怀？并与脑捐赠者保持联系？家庭，告知他们诊断和研究进展。通过科学会议、公众开放日、与慈善机构和MRC通讯的合作，传播和推广脑库知识。为神经科学家提供专业的教学、培训、信息和教育资源。促进基础研究科学家、病理学家和临床医生之间的合作，促进过渡性研究，以帮助开发新的脑部疾病诊断和治疗策略。在保存冷冻和福尔马林固定的大脑方面保持卓越的大脑银行的黄金标准。遵循脑库最佳实践的最新伦理原则，从招募捐赠者和同意验尸到组织请求，并严格遵守《人类组织法》的指导方针。

The Brain Bank collects post-mortem brain tissue from persons with neurodegenerative diseases, such as dementia and motor neuron disease. Wherever possible data from previous clinical presentations, neuropsychological tests and neuroimaging are also collected. The brain tissue is examined by neuropathologists and illness is diagnosed according to internationally agreed criteria. Samples of brain tissue in various fixation states, such as frozen and formalin-fixed, are then made available to Neuroscience research centers along with, where available, spinal cord tissue and cerebrospinal fluid. The purpose of the project is to provide clinically studied and pathologically verified brain tissue to facilitate and promote internationally competitive research into Neurodegenerative disease.The Brain Bank aims are to fulfill international recommendations and guidelines with regard to brain tissue banking. As such, this involves the systematic and focused collection of well-characterised post-mortem material and its subsequent distribution to research groups both regionally and nationally. This will necessarily underpin high quality and peer-reviewed research. The following is a summary of the key functions of the Brain Bank: 1. To advance the understanding of, and facilitate research into the underlying causes of neurodegenerative and neurological diseases through the provision of clinically and neuropathologically well-characterised brain tissue to the research community. 2. To facilitate brain donation through an ethically approved programme of informed consent for cohort studies and ad-hoc donation.3. To provide pathological diagnosis to the relatives of brain donors according to best national and international protocols.4. To coordinate the processing and dissemination of well-preserved brain tissue for clinical, biochemical, molecular pathology, genetic and transcriptional research projects, and maintain an open door policy of responding to requesters without prejudice.5. To ensure ?donor care? and keep contact with ?brain donor? families, informing them about diagnosis and progress in research.6. To disseminate and promote knowledge of brain banking through scientific meetings, public open days, collaboration with charities and MRC newsletters.7. To provide professional teaching, training, information and educational resources for neuroscientists.8. To facilitate collaboration between basic research scientists, pathologists and clinicians to promote transitional research to help develop new diagnostic and therapeutic strategies for brain diseases.9. To maintain gold standards of excellence in Brain Banking for storage of frozen and formalin-fixed brains.10. To follow most recent ethical principles for best practice in Brain Banking, from recruiting donors and consent for postmortem to tissue requests and follow strictly the guidelines of the Human Tissue Act.