NEUROBEHAVIORAL STUDIES OF ALCOHOL TOLERANCE

这里提出的研究将调查神经行为决定因素 乙醇耐受性及乙醇的增强作用。 慢性注射乙醇对脑影响的测定 在大鼠的多个脑部位进行刺激奖赏(BSR)。 将在每个大脑同时测量BSR的三个参数 地点：奖赏阈值、反应率和平均脑阻抗。 一种行为研究设计，允许确定“习得的”与 将采用“未学到的”宽容。实验设计为1。 系统调查急性和慢性乙醇给药情况 特定的大脑定位，2.决定习得和未习得的耐受效应 关于每个部位的BSR，3.研究单胺类神经递质系统 在习得的和不习得的容忍中，以及4.考察所选择的角色 习得性和非习得性耐受中的神经激素系统。随着时间的推移 在允许的情况下，对两者的条件性因素进行额外的研究 耐受性、其他神经递质和神经肽以及其他药物 与乙醇“交叉耐受”的将被调查。 建议的研究包括行为(心理)、药理学和 生化的。他们应该共同为Etoh提供重要的信息 乙醇和脑内调节部位产生的耐受性增强 这些影响。

The research proposed here will investigate neurobehavioral determinants of ethanol (ETOH) tolerance and the reinforcing effects of ETOH. Determination of the effects of chronic injection of ETOH on brain stimulation reward (BSR) at several brain sites of rats will be made. Three parameters of BSR will be measured simultaneously at each brain site: threshold of reward, rate of response and average brain impedance. A behavioral research design which permits determination of "learned" vs "unlearned" tolerance will be employed. Experiments are designed to 1. systematically investigate acute and chronic ETOH administration at specific brain loci, 2. determine learned and unlearned tolerance effects on BSR at each site, 3. investigate monoaminergic neuro-transmitter systems in learned and unlearned tolerance, and 4. examine the role of selected neurohormone systems in learned and unlearned tolerance. With time permitting, additional investigations of conditioning factors in both tolerance, other neuro-transmitters and neuropeptides, and other drugs which are "cross-tolerant" with ETOH will be investigated. The proposed studies are behavioral (psychological), pharmacological and biochemical. They should collectively shed important light on ETOH tolerance reinforcement produced by ETOH and brain sites which mediate these effects.