RECOVERY AND REGENERATION AFTER NEURON INJURY

该项目计划是对以下影响的持续调查 对脊髓神经或脊髓束的损伤 脊椎动物脊髓神经元的组织。这个项目的总体目标是 程序是提供关于功能有效程度的数据 脊髓神经元及其连接的再生或重组可以 发生在未成熟或成熟的脊椎动物神经系统中。每一位 Projects在赤字方面遭遇了对应的或起点 脊髓疾病或创伤性损伤后的人类和/或 脊髓神经元的神经突起。这些方法包括 跨学科并采用动物模型，在该模型中， 生理、形态、生化和行为测量是 以各种方式组合以测试以下示例：a)再生或 脊椎动物脊椎通路的重组，b)脊椎动物 术后累及肾脏和膀胱的脊髓反射的组织 脊髓损伤，c)有利于功能有效的条件 异体神经对膀胱的再支配，d)因子 与再神经支配和再生的特异性有关 交感神经节前神经元的损伤，e)利用的变化 细胞骨架蛋白合成中的氨基酸及其修饰 轴突损伤后的运动神经元胞体，f)修饰 损伤后细小传入纤维向脊髓的投射 背根及其相关功能特性的改变 板层I和II中的神经元，以及g)对下丘脑 初级传入纤维的化学标记，如脊髓中的多肽 脊椎上升通路损伤后的灰质。

This program of projects is a continuing investigation of the effects of injury to spinal nerves or to spinal cord tracts upon the functional organization of vertebrate spinal neurons. The overall goal of this program is to provide data on the degree that functionally-effective regeneration or reorganization of spinal neurons and their connections can take place in immature or mature vertebrate nervous systems. Each of the projects has its counterpart or point of departure in deficits suffered by human beings after disease or traumatic injury of the spinal cord and/or of the nervous processes of spinal neurons. The approaches are interdisciplinary and employ animal models in which combinations of physiological, morphological, biochemical and behavioral measures are combined in various ways to test for examples of: a) regeneration or reorganization of spinal pathways in vertebrates, b) changes in the organization of spinal reflexes involving the kidney and bladder after spinal cord injury, c) conditions favoring functionally effective reinnervation of the urinary bladder by foreign nerves, d) factors associated with the specificity of reinnervation and regeneration after injury of sympathetic preganglionic neurons, e) changes in utilization of amino acids and associated modification in cytoskeletal protein synthesis by motoneuron cell bodies after injury of their axons, f) modifications of the projections into the spinal cord of thin afferent fibers after injury of dorsal roots and associated alterations in functional properties of neurons in laminae I and II, and g) modifications in the distribution of chemical markers for primary afferent fibers such as peptides in the spinal gray matter after injury of ascending spinal pathways.