Acinetobacter baumannii: genomic profiling of an emerging hospital pathogen

鲍曼不动杆菌是一种能引起医院危重病人感染的细菌。它有引起医院暴发的令人担忧的倾向，以及对多种抗生素产生抗药性的令人担忧的能力。不动杆菌感染也成为伊拉克和阿富汗战争中回国人员的一个特别威胁。关于这种微生物如何传播、致病和抵抗抗生素，我们的知识中仍然存在严重的差距。在这项提案中，我们召集了一个由伯明翰大学、国家卫生服务和健康保护局的研究人员组成的跨学科团队，以开发一种新的尖端方法(高通量细菌基因组测序)来填补这些空白，并增进我们对多重耐药鲍曼不动杆菌的理解。

Acinetobacter baumannii is a bacterium that causes infections in critically ill patients in hospital. It has an alarming propensity to cause hospital outbreaks and a worrying ability to acquire resistance to multiple antibiotics. Acinetobacter infection has also emerged as a particular threat to returning casualties of the Iraq and Afghanistan wars. Serious gaps remain in our knowledge as to how this organism spreads, causes disease and resists antibiotics. In this proposal, we have assembled an inter-disciplinary team of researchers from the University of Birmingham, the National Health Service and the Health Protection Agency to exploit a new cutting-edge approach (high-throughput bacterial genome sequencing) to fill these gaps and advance our understanding of multi-drug resistant Acinetobacter baumannii.