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The MRC Consortium for Medical Microbial Bioinformatics

MRC 医学微生物生物信息学联盟

基本信息

批准号：
MR/L015080/1
负责人：
Mark Pallen
金额：
$ 979.12万
依托单位：
University of Warwick
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2014
资助国家：
英国
起止时间：
2014 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FL015080%2F1
关键词：
MRC Consortium Medical Microbial Bioinformatics

项目摘要

The UNIVERSITY OF WARWICK and SWANSEA UNIVERSITY, in partnership with the UNIVERSITY OF BIRMINGHAM and CARDIFF UNIVERSITY, propose a programme of capital expenditure, recruitment and training to create the MRC CONSORTIUM FOR MEDICAL MICROBIAL BIOINFORMATICS, a state-of-the-art interdisciplinary facility, led by Professor Mark Pallen (an MD PhD at Warwick) and Dr Sam Sheppard in Swansea, for use by the academic, industrial and healthcare communities that will enhance regional and national capability and infrastructure in microbial bioinformatics and improve our understanding of bacteria of medical importance. RATIONALE: Microbial pathogens still present a MAJOR EXISTENTIAL THREAT to humanity. In addition, the HUMAN MICROBIOME - the rich and dynamic community of host-associated microorganisms and their genes - is now known to play a decisive role in the balance between health and disease, even in medical conditions not usually considered as microbial in origin (e.g. obesity). Harnessing medical bioinformatics to the study of microbial genes, genomes and metagenomes thus represents a DISTINCTIVE UNMET CHALLENGE and a UNIQUE FOCUS AMONG RESPONSES TO THIS MRC CALL. Rather than taking aim at the fixed, relatively tractable target of the human genome, we focus instead on genomic information derived from HUNDREDS OF BACTERIAL PATHOGENS and THOUSANDS OF COMMENSAL SPECIES: a distributed and dynamic system of MANY MILLIONS OF GENES, at least two orders of magnitude larger than the human gene set. Our four research-active universities are located in neighbouring regions of the UK, thus providing an initial GEOGRAPHICAL COHESION to the Consortium that will facilitate community building and the exchange of ideas, and underpin the formalities of governance. At its inception, the Consortium will benefit from a NATIONAL AND GLOBAL REACH through a dense network of collaborations, collegiality and, through an application process for new partners, will soon grow in a scalable fashion to embrace a national remit. The Consortium will build on TRACK RECORDS OF INDIVIDUAL RESEARCH EXCELLENCE and impressive INSTITUTIONAL INVESTMENT in medical microbiology and bioinformatics with all partners making a distinctive contribution. Through this initiative we will recruit THREE HIGHLY TALENTED INDIVIDUALS into microbial bioinformatics fellowships from careers outside the discipline or the country. We have LEVERAGED SUPPORT from the host organisations to place these research fellows on a TENURE TRACK. All three fellows will contribute to the goals of the Consortium through research, training and management roles as well as pushing forward their own cutting-edge research programmes. Building on interests in parallelisation and cloud computing, we will develop a DISTRIBUTED COMPUTING INFRASTRUCTURE in Wales and the West Midlands that will provide an agile, scalable system for the UK microbiology research community.We will develop an ambitious and exciting TRAINING PROGRAMME that will include bootcamps, hackathons, workshops, modules and courses, suitable for a wide range of users from professional bioinformaticians to undergraduate students.We will strengthen regional, national and international microbial bioinformatics research through COMMUNITY-BUILDING ACTIVITIES, encouraging knowledge transfer and dissemination of best practice. Meetings of different sorts and scale will be held monthly and quarterly and annually. The Annual Meeting, with an academic and management component, will benefit from participation by our external Steering Group. We will exploit pump-priming funds together with externally funded research activities to "stress our systems", confirming that the facilities that we have created work as planned and/or priming iterative refinements to our infra-structure. We are confident that the consortium will become self-sustaining through institutional commitments and the recruitment of additional research funding.

华威大学和斯旺西大学与伯明翰大学和卡迪夫大学合作，提出了一项资本支出、招聘和培训计划，以创建医学微生物生物信息学 MRC 联盟，这是一个最先进的跨学科设施，由 Mark Pallen 教授（华威大学医学博士）和斯旺西的 Sam Sheppard 博士领导，供学术界、工业界和医疗保健社区将增强区域和国家在微生物生物信息学方面的能力和基础设施，并提高我们对具有医学重要性的细菌的了解。理由：微生物病原体仍然对人类构成重大的生存威胁。此外，人类微生物组——宿主相关微生物及其基因的丰富而动态的群落——现在已知在健康与疾病之间的平衡中发挥着决定性作用，即使在通常不被认为是微生物起源的医疗条件下（例如肥胖）也是如此。因此，利用医学生物信息学来研究微生物基因、基因组和宏基因组是一个独特的未满足的挑战，也是响应 MRC 号召的独特焦点。我们不是瞄准人类基因组中固定的、相对容易处理的目标，而是关注源自数百种细菌病原体和数千种共生物种的基因组信息：一个由数百万个基因组成的分布式动态系统，比人类基因集至少大两个数量级。我们的四所研究活跃的大学位于英国邻近地区，从而为联盟提供了初步的地理凝聚力，这将促进社区建设和思想交流，并巩固治理的形式。在成立之初，该联盟将通过密集的合作网络、合作关系以及新合作伙伴的申请流程，从全国和全球影响力中受益，并将很快以可扩展的方式发展，以涵盖全国范围。该联盟将建立在医学微生物学和生物信息学方面的个人研究卓越记录和令人印象深刻的机构投资的基础上，所有合作伙伴都做出了独特的贡献。通过这一举措，我们将从学科或国家以外的职业中招募三名高素质人才加入微生物生物信息学奖学金。我们得到了主办组织的支持，将这些研究人员纳入终身教职。所有三位研究员都将通过研究、培训和管理角色以及推动自己的前沿研究项目为联盟的目标做出贡献。基于对并行化和云计算的兴趣，我们将在威尔士和西米德兰兹开发分布式计算基础设施，为英国微生物学研究界提供灵活、可扩展的系统。我们将开发一个雄心勃勃且令人兴奋的培训计划，其中包括训练营、黑客马拉松、研讨会、模块和课程，适合从专业生物信息学家到本科生的广泛用户。我们将加强通过社区建设活动开展区域、国家和国际微生物生物信息学研究，鼓励知识转移和传播最佳实践。每月、每季度、每年召开不同种类、不同规模的会议。年会包含学术和管理部分，我们的外部指导小组的参与将受益匪浅。我们将利用泵启动资金以及外部资助的研究活动来“对我们的系统施加压力”，确认我们创建的设施按计划运行和/或启动对我们的基础设施的迭代改进。我们相信，该联盟将通过机构承诺和招募额外的研究资金实现自我维持。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.

通过靶向亚基界界面来抑制分枝杆菌色氨酸合酶。

DOI：
10.1038/s41598-017-09642-y
发表时间：
2017-08-25
期刊：
Scientific reports
影响因子：
4.6
作者：
Abrahams KA;Cox JAG;Fütterer K;Rullas J;Ortega-Muro F;Loman NJ;Moynihan PJ;Pérez-Herrán E;Jiménez E;Esquivias J;Barros D;Ballell L;Alemparte C;Besra GS
通讯作者：
Besra GS

A large outbreak of COVID-19 in a UK prison, October 2020 to April 2021.

DOI：
10.1017/s0950268822000991
发表时间：
2022-05-30
期刊：
EPIDEMIOLOGY AND INFECTION
影响因子：
4.2
作者：
Adamson, James P.;Smith, Christopher;Pacchiarini, Nicole;Connor, Thomas Richard;Wallsgrove, Janet;Coles, Ian;Frost, Clare;Edwards, Angharad;Sinha, Jaisi;Moore, Catherine;Perrett, Steph;Craddock, Christie;Sawyer, Clare;Waldram, Alison;Barrasa, Alicia;Thomas, Daniel Rh;Daniels, Philip;Lewis, Heather
通讯作者：
Lewis, Heather

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