MRC Network of UK Brain Banks: Support for the Coordinating Centre

在应对不断增加的阿尔茨海默氏症、S病和帕金森S病等进行性神经系统疾病患者方面，英国正面临着医疗服务、护理人员和经济的重大挑战。随着人口老龄化，越来越多的人可能患上这些疾病，这将提高我们对这些疾病的认识、大脑受损的机制以及在活着的患者中寻找新的治疗和更好的诊断测试的机会放在了高度优先的位置。英国脑库网络的目的是通过向英国的研究人员提供最高质量的脑组织样本来支持这项重要的研究。该网络还将解决作为疾病组织样本对照材料所需的正常组织样本短缺的问题。该网络将允许其成员以更协调的方式共同工作，从而产生更灵活和更具成本效益的运作。该网络为研究人员带来的好处也将通过创建一个网站来增加，该网站允许人们轻松获取存储在英国各地银行的脑组织样本的性质和类型的信息。该网络还将利用该网站向潜在的脑组织捐赠者提供新的信息，并将这些信息用于在该网络的一个银行运作的最合适的捐赠者计划。因此，该项目将使更多的研究成为可能，不仅是阿尔茨海默病？S病，而且是更广泛的神经和神经精神疾病，如运动神经元疾病和精神分裂症。这些破坏性的疾病是21世纪医疗保健的主要挑战，已被确定为NHS的优先领域。该网络将支持英国已经开展的优秀研究，并使其能够以比目前可能的速度更快的速度进一步发展。该网络还将为公众提供一个重点，让他们更多地了解脑组织捐赠，这种提高的意识也将有助于支持英国的研究。

The UK is facing a major challenge to health services, carers and the economy in dealing with the increasing numbers of individuals who are suffering from progressive neurological diseases such as Alzheimer?s disease and Parkinson?s disease. As the population ages, increasing numbers of individuals are likely to develop these diseases and this places a high priority on improving our knowledge of these diseases, the mechanisms through which the brain is damaged, and identifying new opportunities for treatment and for better diagnostic tests in living patients. The aim of the Network of UK brain banks is to support this vital research by making brain tissue samples of the highest quality available to researchers in the UK. The Network will also address the shortage of normal tissue samples that are required as control material for the disease tissue samples. The Network will allow its members to work together in a more co-ordinated way, resulting in a more flexible and cost-efficient operation. The benefits of the Network for researchers will also be increased by creating a website that allows easy access to information on the nature and type of brain tissue samples stored in the various banks across the UK. The Network will also use the website to provide new information to potential brain tissue donors, and will direct these towards the most appropriate donor scheme operating at one of the banks in the Network. This project will therefore enable more research, not just into Alzheimer?s disease but into a wider range of neurological and neuropsychiatric diseases, such as motor neurone disease and schizophrenia. These devastating disorders represent a major challenge for 21st century health care and have been identified as a priority area for the NHS. This Network will support the excellent research already being undertaken in the UK, and allow it to develop further at a faster rate than currently is possible. The Network will also provide a focus for the general public in understanding more about brain tissue donation, and this increased awareness will also help support research in the UK.