A clinical investigation into the abnormal apoptotic response associated with Crohn's disease

克罗恩病?S疾病是一种慢性炎症，可以影响肠道的任何部位。其原因尚不清楚，但被认为是由于肠道细菌与身体之间的异常相互作用而发生的。免疫系统。西格尔教授?s的实验室最近提供了证据，证明克罗恩病患者对肠道细菌有异常的免疫反应。年代的疾病。在研究克罗恩病患者的免疫反应的过程中？S疾病，我们已经确定了一个异常的自然发生的过程称为？细胞程序性死亡？或凋亡。细胞凋亡是指为了维持个体的健康，某些细胞被移除的过程。细胞凋亡异常见于癌症的发展，但也见于有慢性炎症因素的情况。我们认为克罗恩的细胞凋亡异常？S型疾病患者允许这些细胞驱动肠道中的慢性炎症。拟开展的研究项目将探讨克罗恩？我们将详细研究S疾病，并有望发现控制这一过程的缺陷分子和化学途径，从而开发出新的治疗方案。

Crohn?s disease is a chronic inflammatory condition that can affect any part of the gut. The cause of this is unknown but thought to occur because of abnormal interaction between the gut bacteria and the body?s immune system. Professor Segal?s laboratory has recently provided evidence of an abnormal immune response to gut bacteria in patients with Crohn?s disease. In the process of this research into the immune response in patients with Crohn?s disease, we have identified an abnormality in the naturally occurring process termed ?programmed cell death? or apoptosis. Apoptosis is the process by which certain cells are removed for the body in order to maintain the well being of an individual. Abnormalities in apoptosis are seen in the development of cancers, but also in conditions in which there is a chronic inflammatory element. We believe that an abnormality in apoptosis in Crohn?s disease patients allows these cells to drive the chronic inflammation seen in the gut. The proposed research project will investigate the abnormal apoptotic response in Crohn?s disease in detail and will hopefully result in the identification of defective molecules and chemical pathways that control this process hopefully leading to the development of new treatment options.