Molecular Biology of Salivary Insulin and Glucagon

唾液胰岛素和胰高血糖素的分子生物学

• 批准号: 8615740
• 负责人: Phillip Smith
• 金额: $ 7万
• 依托单位: SUNY at Albany
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-15 至 1990-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8615740&HistoricalAwards=false
• 关键词: Molecular; Biology; Salivary; Insulin; Glucagon

Dr. Smith plans to study the homology between the insulin and glucagon produced by the pancreas and the insulin and glucagon produced by salivary glands using the rat as an animal model. These hormones are important in the regulation of metabolism and food stuff utilization. A deficiency of pancreactic insulin production results in diabetes. Smith has evidence that the peptides produced by the two glands are identical in terms of peptides structure and the genes that regulate production. However, the pancreatic peptides are secreted into the blood and act as hormones, whereas the salivary gland peptides are secreted into the gastrointestinal tract and have no known function. Smith hopes to be able to determine mechanisms regulating production, processing and secretion of the salivary gland peptides as compared to the pancreatic peptides in rats of varying ages or stages of development and under various hormonal conditions including the diabetic state. Apparently, the salivary gland peptides are produced in the diabetic state indicating some differences in the regulation of gene expression between the two glands that might lead to a better understanding of the hormonal and genetic regulation of insulin and glucagon production and to possible mechanisms for gene or cell transfer to relieve the diabetic state.

史密斯博士计划以大鼠为动物模型，研究胰腺产生的胰岛素和胰高血糖素与唾液腺产生的胰岛素和胰高血糖素之间的同源性。这些激素在调节新陈代谢和食物利用方面起着重要作用。胰腺胰岛素分泌不足导致糖尿病。史密斯有证据表明，两个腺体产生的肽在肽结构和调节产生的基因方面是相同的。然而，胰腺肽作为激素分泌到血液中，而唾液腺肽分泌到胃肠道中，没有已知的功能。Smith希望能够确定在不同年龄或发育阶段以及包括糖尿病状态在内的各种激素条件下，与胰腺肽相比，唾液腺肽的产生、加工和分泌的调节机制。显然，唾液腺肽是在糖尿病状态下产生的，这表明两个腺体之间的基因表达调控存在一些差异，这可能有助于更好地理解胰岛素和胰高血糖素产生的激素和遗传调控，以及基因或细胞转移以缓解糖尿病状态的可能机制。