Integrated nanoscopy and microscopy in 3-D to study hippocampal neurogenesis at the synaptic and molecular level.

这项研究计划旨在分析与进食相关的激素在刺激新脑细胞产生中的作用。生成新的成年脑细胞的能力对于正常健康的大脑功能非常重要。形成新神经元的能力下降与常见的大脑疾病、痴呆症和抑郁症有关。这项研究将使用工程师建立的最先进的工具，使我们能够比以前更详细地观察脑细胞。这些纳米尺度的工具在神经科学中的应用将提供关于脑细胞精确结构和功能的宝贵信息。最终，这种新方法将揭示新脑细胞生成的机制，从而为治疗痴呆症和抑郁症提供新的靶点。

This research proposal aims to analyse the role of a feeding-associated hormone in stimulating the generation of new brain cells. The ability to generate new adult brain cells is very important for normal healthy brain function. A reduced ability to form new neurones is associated with the common and debilitating brain disorders, dementia and depression.This research will use state-of-the-art tools, established by engineers, that will allow us to look at brain cells in far greater detail than previously possible. The application of these nano-scale tools to neuroscience will provide invaluable information on the precise structure and function of brain cells over time. Ultimately, this novel approach will characterise the mechanism of new brain cell generation leading to new targets for the treatment of dementia and depression.