EFFECT OF SOCIAL DRINKING ON BLOOD PRESSURE

高血压在美国成年人中很常见。 它 已被证明与心血管疾病的增加有关 发病率和死亡率。 酒精消费也很普遍， 在多达三分之一的疾病中起着重要的致病或促进作用， 高血压 高血压与酒精的关系 消费有待因果解释，这是本研究的目的。 将使用24小时动态血压测量血压 正常血压和高血压人群的连续数日监测系统 饮酒者在正常饮酒和戒酒期间。 受试者在研究期间将接受低单胺饮食。 将在基线或平时饮酒期间采集血液和尿液样本 饮酒、戒酒和恢复到基线酒精摄入水平 用于测量神经递质、神经调质和电解质 参与血压调节。 这些监管制度的变化 在研究的三个阶段中与血压相关。

Hypertension is common in the adult population of the United States. It has been demonstrated to be associated with increased cardiovascular morbidity and mortality. Alcohol consumption is also prevalent and may play an important causative or contributory role in up to one-third of all hypertensives. The association between hypertension and alcohol consumption awaits causative explanation and is the purpose of this study. Blood pressure will be measured using a 24-hour ambulatory blood pressure monitoring system for several days in normotensive and hypertensive social drinkers during periods of usual alcohol consumption and abstinence. Subjects will be on a low monoamine diet for the duration of the study. Blood and urine samples will be obtained during baseline or usual alcohol consumption, abstinence, and return to baseline levels of alcohol intake for measurement of neurotransmitters, neuromodulators, and electrolytes involved in blood pressure regulation. Changes in these regulatory systems will be related to blood pressure in the three phases of the study.