Design and implementation of a human challenge model for Neisseria gonorrhoeae

淋病是一个重大的公共卫生问题，可导致严重疾病并促进艾滋病毒的传播。淋病感染在全球范围内不断增加，抗生素耐药性淋病的传播是一个严重的健康威胁。本研究旨在为男性咽喉和生殖器淋病感染开发一种受控感染模型，以提高对淋病感染的科学认识和对新型抗生素治疗的反应;并为疫苗开发提供见解。

Gonorrhoea is a major public health problem that can lead to severe disease and promote the spread of HIV. Gonorrhoea infections are increasing worldwide and the spread of antibiotic resistant gonorrhoea is a critical health threat. This study aims to develop a controlled infection model for male throat and genital gonorrhoea infection in order to improve scientific understanding of gonorrhoea infection and responses to novel antibiotic treatment; and provide insights into vaccine development.