Improving Family Cancer History Collection using Social Network, Human Centered Design, and Implementation Science Approaches

项目概要 F99/K00提案中包含的研究策略和培训计划将促进职业发展 凯特琳·艾伦 (Caitlin G. Allen) 公共卫生硕士的研究独立性。该研究计划旨在增进有关如何 扩大现有循证遗传学工具（例如家族癌症史 (FCH)）的范围和采用 服务不足的少数民族人口。 FCH 收集是一种简单、行之有效的方法来识别个体的遗传 患癌症的风险，可以鼓励针对性的癌症预防和风险分层筛查。尽管 尽管各国努力，FCH 收集仍然不够理想，尤其是在收集方面存在显着差异 非裔美国人 (AA) 家庭。艾伦女士的 F99 研究和培训将侧重于培养她的社交技能 网络分析，研究导致 FCH 知识匮乏的个人和家庭网络因素。女士 Allen 已经完成了两篇补充论文研究，直接为拟议的 F99 提供信息 研究：1）对家庭健康收集工具进行系统审查，2）开发有效且可靠的量表 用于识别极有可能共享 FCH 信息的家庭网络成员。她会完成她的 该奖项 F99 阶段的论文研究，其中将涉及：1) 50 名 AA 参与者完成他们的研究 使用 FCH 收集工具 (ItRunsInMyFamily) 的 FCH，以及 2) 表征个人和网络级因素 通过使用有色生态遗传学进行个人网络访谈来影响 FCH 收集 关系图技术。为了实现这些目标，她的 F99 培训目标是：1）磨练专业能力 资助、学术写作和研究传播方面的技能，2）通过以下方式培养科学独立性： 加强社交网络分析和相关研究方法的方法论和分析技能，以及 3）确定博士后站点和K00导师。艾伦女士的F99培训计划得到了来自以下机构的大力支持 罗林斯公共卫生学院优秀的导师团队和埃默里大学的研究基础设施 大学，创造最佳的培养环境。 Allen女士博士后研究（K00阶段）将扩大 基于 F99 的工作，通过以人为本的设计增强 FCH 收集工具 (ItRunsInMyFamily) 方法并在基于社区的临床环境中实施该工具。她的训练目标与此一致 研究阶段包括：1）建立以人为本的设计和卫生技术评估方面的知识， 2) 成为实施科学方面的专家，3) 提高专业和研究技能，做好准备 以获得学术研究职位。总的来说，综合研究计划和培训目标对于 建立成功、创新且有意义的学术生涯，专注于扩展癌症特异性 通过支持基于证据的解决方案，为边缘化和代表性不足的人群提供遗传学发现 例如 FCH 可以改善癌症预防和早期检测。

PROJECT SUMMARY The research strategy and training plan included in this F99/K00 proposal will enhance the career development and research independence of Caitlin G. Allen, MPH. This research plan aims to advance knowledge of how to expand the reach and uptake of existing evidence-based genetics tools such as family cancer history (FCH) among underserved minority populations. FCH collection is a simple, proven way to identify individual's genetic risk for developing cancer that can encourage tailored cancer prevention and risk-stratified screening. Despite national efforts, FCH collection remains suboptimal with especially noteworthy disparities in collection among African American (AA) families. Ms. Allen's F99 research and training will focus on developing her skills in social network analysis to study individual and family network factors that contribute to poor knowledge of FCH. Ms. Allen has already completed two complementary dissertation studies that directly inform the proposed F99 research: 1) a systematic review of family health collection tools, and 2) development of a valid and reliable scale used to identify family network members that are highly likely to share FCH information. She will complete her dissertation research in the F99 phase of this award, which will involve: 1) 50 AA participants completing their FCH using a FCH collection tool (ItRunsInMyFamily), and 2) characterizing individual- and network-level factors that influence FCH collection by conducting personal network interviews using the Colored Eco-Genetic Relationship Map technique. To accomplish these aims, her F99 training objectives are to: 1) hone professional skills in grantsmanship, academic writing, and research dissemination, 2) develop scientific independence by strengthening methodological and analytic skills in social network analysis and relevant research methods, and 3) identify a postdoctoral site and K00 mentor. Ms. Allen's F99 training plan is bolstered by strong support from an excellent mentorship team at the Rollins School of Public Health and the research infrastructure at Emory University, creating an optimal training environment. Ms. Allen's postdoctoral research (K00 phase) will expand upon F99 work by enhancing a FCH collection tool (ItRunsInMyFamily) through human centered design approaches and implementing this tool in community-based clinical settings. Her training goals aligned with this phase of research includes: 1) building knowledge in human centered design and health technology assessment, 2) becoming an expert in implementation science, and 3) enhancing professional and research skills to prepare for an academic research position. Collectively, the integrated research plan and training goals are critical to establishing a successful, innovative, and meaningful academic career focused on extending cancer-specific genetics discoveries to marginalized and underrepresented populations by supporting evidence-based solutions such as FCH to improve cancer prevention and early-detection.