BLOOD CHEMISTRY PROFILES AND ETHANOL DEPENDENCE

本文研究了乙醇对大鼠血浆脂蛋白的影响。 测定极低密度脂蛋白(VLDL)、低密度脂蛋白 单次给药后的脂蛋白(LDL)和高密度脂蛋白(HDL) 酒精依赖大鼠给予6g/kg乙醇。三个特点 在酒精灌胃过程中，区分大鼠的神经行为组 戒断时间：(1)依赖中毒(前驱)组(2) 明显戒断综合征组；(3)惊厥发作组。不是 所有脂蛋白在24小时后都有显著变化。 单剂量的乙醇。酒精依赖大鼠极低密度脂蛋白降低，高密度脂蛋白 增加，低密度脂蛋白水平没有明显变化。这些 数据表明，用药后大鼠血液中高密度脂蛋白的升高 4天的酒精含量与人类酗酒者体内的含量相似。

The blood plasma lipoprotein profile in ethanol-treated rats was studied by determining the levels of very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) after a single dose (6 g/kg) of ethanol in ethanol-dependent rats. Three characteristic neurobehavioral groups of rats were distinguished during the ethanol withdrawal period: (1) the dependent intoxicated (prodromal) group (2) the overt withdrawal syndrome group, and (3) the convulsive seizure group. No significant changes in any lipoproteins were found up to 24 hours after the single dose of ethanol. In the ethanol-dependent rats, VLDL decreased, HDL increased, and no significant change in the LDL levels occurred. These data suggest that elevation of HDL in the blood of rats treated with ethanol for 4 days is similar to that found in human alcoholics.