London Neurodegenerative Diseases Brain Bank; a national resource for neuroscience research

脑库收集患有神经退行性疾病（如痴呆症和运动神经元疾病）的人的死后脑组织。在可能的情况下，还收集了以前临床检查、神经心理学测试和神经成像的数据。脑组织由神经病理学家检查，疾病根据国际公认的标准进行诊断。大脑和脊髓组织的样本在不同的固定状态，如冷冻和福尔马林固定，然后提供给神经科学研究人员。该项目的目的是提供临床研究和病理学验证的脑组织，以促进和促进神经退行性疾病的国际竞争性研究。脑库的目标是履行关于脑组织库的国际建议和指导方针。因此，这涉及到系统和有重点地收集具有良好特征的死后材料，并随后将其分发给区域和国家的研究小组。这必然会支持高质量和同行评审的研究。以下是脑库的主要功能概述：1。通过向研究界提供临床和神经病理学特征良好的脑组织，促进对神经退行性疾病和神经系统疾病根本原因的理解和研究。2.通过伦理上批准的知情同意捐赠计划促进大脑捐赠。3.根据最好的国家和国际协议，为脑捐赠者的亲属提供病理诊断。4.协调保存完好的脑组织的处理和传播，并保持对请求者不带偏见的开放政策。5.确保捐献者的护理，并与脑捐献者家属保持联系，告知他们诊断和研究进展。6.通过科学会议、公众开放日、与慈善机构的合作以及MRC通讯，传播和推广脑库知识。7.为神经科学家和医学实习生提供专业的教学、培训、信息和教育资源。8.促进基础研究科学家，病理学家和临床医生之间的合作，以促进过渡性研究，以帮助开发新的诊断和治疗脑疾病的策略。9.保持脑银行在储存冷冻和福尔马林固定脑组织方面的黄金标准。10.遵循最新的脑库最佳实践伦理原则，从同意捐赠者到组织请求，并严格遵守《人体组织法》的指导方针。

The Brain Bank collects post-mortem brain tissue from persons with neurodegenerative diseases, such as dementia and motor neuron disease. Wherever possible data from previous clinical examinations, neuropsychological tests and neuroimaging are also collected. The brain tissue is examined by neuropathologists and disease is diagnosed according to internationally agreed criteria. Samples of brain and spinal cord tissue in various fixation states, such as frozen and formalin-fixed, are then made available to Neuroscience researchers. The purpose of the project is to provide clinically studied and pathologically verified brain tissue to facilitate and promote internationally competitive research into Neurodegenerative disease. The Brain Bank aims are to fulfill international recommendations and guidelines with regard to brain tissue banking. As such, this involves the systematic and focused collection of well-characterised post-mortem material and its subsequent distribution to research groups both regionally and nationally. This will necessarily underpin high quality and peer-reviewed research. The following is a summary of the key functions of the Brain Bank: 1. To advance the understanding of, and facilitate research into the underlying causes of neurodegenerative and neurological diseases through the provision of clinically and neuropathologically well-characterised brain tissue to the research community. 2. To facilitate brain donation through an ethically approved programme of informed consent for donation. 3. To provide pathological diagnosis to the relatives of brain donors according to best national and international protocols. 4. To coordinate the processing and dissemination of well-preserved brain tissue and maintain an open door policy of responding to requesters without prejudice. 5. To ensure donor care and keep contact with brain donor families, informing them about diagnosis and progress in research. 6. To disseminate and promote knowledge of brain banking through scientific meetings, public open days, collaboration with charities and MRC newsletters. 7. To provide professional teaching, training, information and educational resources for neuroscientists and medical trainees. 8. To facilitate collaboration between basic research scientists, pathologists and clinicians to promote transitional research to help develop new diagnostic and therapeutic strategies for brain diseases. 9. To maintain gold standards of excellence in Brain Banking for storage of frozen and formalin-fixed brain tissue. 10. To follow most recent ethical principles for best practice in Brain Banking, from consenting donors to tissue requests and strictly follow the guidelines of the Human Tissue Act.