MICROBIAL ECOLOGY AND ITS RELATION TO DENTAL DISEASES

这项提案提出了一个广泛的计划，其目标是提供关键部分 更好地了解病因学和 龋齿和各种形式的牙周病的发病机制；以及 制定合理的控制方法。该程序集成了 研究人员在微生物学领域所经历的努力， 动物实验、电子显微镜、营养学、牙周学和 临床牙科，代表了正在进行的研究的延伸。这个 具体目标包括尝试开发和完善 研究重要的口腔细菌，并研究其性质 引起或影响其致病力的牙病细菌。 其他目的与阐明影响 传播和获取突出的口腔细菌。特别强调 致力于研究影响寄主和环境因素 潜在的重要牙病细菌的定植。包括在内 是关于饮食成分的影响的研究，局部应用 某些氟化物、多形核白细胞及其产品 口腔微生物的抗体、口腔定位和纤维连接蛋白 殖民主义。

This proposal presents a broad program whose goal is to provide key pieces of basic information required to better understand the etiology and pathogenesis of dental caries and various forms of periodontal disease, and to formulate rational approaches for their control. The program integrates the efforts of investigators experienced in the areas of microbiology, animal experimentation, electron microscopy, nutrition, periodontology and clinical dentistry, and represents an extension of on-going studies. The specific aims include attempts to develop and refine methodology for studying important oral bacteria, and studies of the properties of odontopathic bacteria which account for, or influence their virulence. Other aims relate to elucidating parameters which influence the transmission and acquisition of prominent oral bacteria. Special emphasis is being devoted to studies of host and environmental factors which affect the colonization of potentially- important odontopathic bacteria. Included are studies of the influence of dietary components, topically-applied fluorides, polymorphonuclear leucocytes and their products, certain antibodies, intraoral location, and fibronectin on oral microbial colonization.