Understanding equine incretins: a novel approach to laminitis prevention

蹄叶炎是马的一种致残性足病，会造成重大的经济和社会损失。最近的研究表明，持续的高胰岛素浓度可引发蹄叶炎，而高胰岛素水平是由称为肠促胰岛素的激素过度释放引起的。本项目旨在确定肠促胰岛素及其受体在引起马胰岛素分泌异常中的作用。马肠促胰岛素受体的分布将首次描述，肠促胰岛素受体结合的后果将被表征。了解马肠促胰岛素生物学可能会导致新的治疗蹄叶炎。

Laminitis is a crippling foot disease in horses which incurs significant economic and social costs. Recent studies have shown that persistently high insulin concentrations can trigger laminitis, and that high insulin levels are caused by the excessive release of hormones called incretins. This project aims to determine the role of incretins and their receptors in causing abnormal equine insulin secretion. The distribution of equine incretin receptors will be described for the first time, and the consequences of incretin receptor binding will be characterised. Understanding equine incretin biology may lead to novel therapies for laminitis.