SLEEP, TEMPERATURE AND ACTIVITY CHANGES IN WOMEN WITH PREMENSTRUAL SYNDROME

经前综合征（PMS）的症状包括情绪、认知和 在月经前期出现的行为障碍 月经周期 他们可能会变得严重到足以导致自杀 抑郁症或精神病 客观的生理参数， 经前综合症的主观症状，需要加以识别， 进一步描述这种综合征，并可能提出更好的形式， 治疗 首先，这项研究检查了睡眠，温度和活动 在中度至重度乳腺癌患者的月经周期中， 经前期综合征和正常志愿者。 两个月基线 活动记录，客观评级和睡眠，情绪， 能量得到了。 然后受试者被送往医院， 他们每周两个晚上接受睡眠脑电图和体温记录， 一个月经周期的持续时间。 经前综合征可能是情感障碍的一种变体。 因此，治疗方式被认为是有效的，在主要的 情感障碍可能对治疗PMS患者有用。 为 例如，睡眠剥夺会导致情感的短暂缓解， 在经前综合症中也会有同样的作用。 此外，睡眠不足会降低 催乳素和高催乳素血症与情绪有关 经前综合征患者的精神障碍。 因此，睡眠的影响 在这些患者中进行了剥夺研究。 长时间强光 暴露在季节性情感障碍患者的症状。 由于SAD和PMS的症状相似，长时间的强光照射 或者用β受体阻滞剂阿替洛尔治疗， 光，抑制褪黑激素被评估为PMS的可能治疗。 睡眠剥夺和光治疗实验的结果可能会增加 我们对经前综合征的病理生理机制的理解， PMS与情感障碍的关系

The symptoms of premenstrual syndrome (PMS) consist of mood, cognitive, and behavioral disturbances occurring in the premenstrual phase of the menstrual cycle. They may become severe enough to cause suicidal depression or psychosis. Objective physiologic parameters that correlate with the subjective symptoms of PMS need to be identified in order to delineate this syndrome further and possibly to suggest better forms of treatment. First, this study examined sleep, temperature and activity changes across the menstrual cycle in women with moderate to severe premenstrual syndrome and in normal volunteers. Two months of baseline activity recording, objective ratings and self-ratings of sleep, mood, and energy were obtained. Subjects were then admitted to the hospital where they underwent sleep EEG and temperature recordings two nights a week for the duration of one menstrual cycle. Premenstrual syndrome may represent a variant of affective disorder. Therefore, treatment modalities found to be effective in the major affective disorders may be useful in treating patients with PMS. For example, sleep deprivation which induces transient remissions in affective disorder may do the same in PMS. Furthermore, sleep deprivation lowers prolactin, and hyperprolactinemia has been associated with mood disturbances in patients with PMS. Therefore, the effects of sleep deprivation were investigated in these patients. Prolonged intense light exposure alleviates symptoms in patients with seasonal affective disorder. Since symptoms of SAD and PMS are similar, prolonged intense light exposure or treatment with the beta blocking drug, atenolol, which, like bright light, suppresses melatonin was evaluted as a possible treatment for PMS. Results of sleep deprivation and light treatment experiments may increase our understanding of the pathophysiological mechanisms of PMS and the relationship between PMS and affective disorders.