THERMOREGULATORY FUNCTION OF SLOW-WAVE SLEEP AND REM SLEEP

慢波睡眠和快速眼动睡眠的体温调节功能

• 批准号: 3922048
• 负责人: T A WEHR
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3922048
• 关键词: REM sleep; bioenergetics; body temperature regulation; brain; electroencephalography; eye movements; psychophysiology; sleep

The project is designed to investigated basic biological functions of sleep and sleep stages. Sleep, like torpor, may serve to conserve energy by inhibiting behavioral responses to environmental stimuli and by lowering the regulated level of body temperature and metabolism. Such repeated small savings in energy expenditure could enhance an animal's chance of survival in environments with marginal energy resources. Most investigators have focused on energy conserving aspects of slow wave sleep, which appears to be associated with a temperature-lowering mechanism. Current dogma is that thermoregulation is suspended during REM sleep. However, considerable energy is expended by the brain during REM sleep, and it seems unlikely that this expenditure serves no useful purpose. We hypothesize that REM sleep serves to generate heat locally in the brain and the eyes in order to maintain CNS temperature within acceptable limits while the rest of the body cools during sleep. Heat production is accomplished by 1) increased brain metabolism and 2) rapid eye movements. Maintenance of brain temperature may 1) facilitate rapid arousal from sleep and/or 2) protect CNS tissue in homeotherms from functional or structural impairment during the considerable body cooling which occurs when they sleep in a natural environment. The purpose of this project is 1) to document changes in somatic and CNS temperature during the different stages of sleep by measuring sleep EEG and rectal, chest, finger, eyelid, forehead and tympanic membrane temperatures continuously during sleep, and during voluntary rapid eye movements during wakefulness and 2) to test the hypothesis that REM sleep maintains brain temperature during body cooling by testing the response of REM sleep generating mechanisms to thermal challenges administered to the sleeping brain. During slow wave sleep, we found that rectal, forehead, eyelid and tympanic temperatures decline rapidly. During the first REM sleep episode and during voluntary rapid eye movements during wakefulness, we fund that rectal temperature (a measure of somatic temperature) continues to decline, but that forehead, eyelid, and tympanic temperatures (indirect measures of CNS temperature) rise. These descriptive observations are in accord with our model of selective brain thermogenesis during REM sleep. We have begun the effects of facial heating and cooling on REM sleep generating mechanisms. Data from these experiments have not yet been analyzed.

该项目旨在研究基本生物学功能 睡眠和睡眠阶段。 睡眠，就像麻木一样，可能有助于 通过抑制对环境的行为反应来节省能量 刺激并降低体温的调节水平 代谢。 如此反复小幅节省能源支出 可以提高动物在环境中的生存机会 边际能源资源。 大多数研究者都把注意力集中在 慢波睡眠的能量保存方面，这似乎是 与降温机制有关。 目前的教条是在快速眼动睡眠期间暂停体温调节 睡觉。 然而，大脑消耗了大量的能量 在快速眼动睡眠期间，这种支出似乎不太可能 没有任何有用的目的。 我们假设快速眼动睡眠有助于 在大脑和眼睛局部产生热量，以便 将中枢神经系统温度维持在可接受的范围内，而其余部分 睡眠时身体会变冷。 产热完成 通过 1) 增加大脑新陈代谢和 2) 快速眼球运动。 维持大脑温度可能 1) 促进快速觉醒 避免睡眠和/或 2) 保护恒温动物的中枢神经系统组织免受 在相当大的身体过程中，功能或结构受损 当他们在自然环境中睡觉时会发生冷却。 该项目的目的是 1）记录体细胞的变化 睡眠不同阶段的中枢神经系统温度 测量睡眠脑电图和直肠、胸部、手指、眼睑、前额和 睡眠期间鼓膜温度持续升高，以及 清醒期间自愿快速眼球运动期间以及 2) 检验快速眼动睡眠维持大脑温度的假设 在身体冷却期间通过测试快速眼动睡眠产生的反应 对睡眠者进行热挑战的机制 脑。 在慢波睡眠期间，我们发现直肠、前额、 眼睑和鼓室温度迅速下降。 第一次期间 快速眼动睡眠期和自愿快速眼球运动期间 清醒时，我们资助直肠温度（体细胞的测量） 温度）继续下降，但额头、眼睑和 鼓膜温度（中枢神经系统温度的间接测量）升高。 这些描述性观察符合我们的模型 快速眼动睡眠期间的选择性大脑生热作用。 我们已经开始研究面部加热和冷却对快速眼动睡眠的影响 睡眠产生机制。 这些实验的数据并未 尚未分析。