Determinants of cytomegalovirus salivary gland persistence

人巨细胞病毒（HCMV）在唾液腺（病毒传播器官）中持续时间较长。目前尚不清楚病毒如何避免在该组织中的免疫介导的控制。将在小鼠模型中使用两种在唾液腺持久性方面表现出显著差异的鼠CMV毒株评估病毒病理学的这一方面。将研究组织嗜性（细胞凋亡抑制）、病毒免疫逃避和宿主免疫在唾液腺持久性中的作用。

Human cytomegalovirus (HCMV) persists for extended periods in the salivary gland, an organ of viral transmission. It is not clear how the virus avoids immune mediated control in this tissue. This aspect of viral pathology will be assessed in a mouse model using two strains of murine CMV which exhibit marked differences in salivary gland persistence. The role of tissue tropism (inhibition of apoptosis), viral immune evasion and host immunity in salivary gland persistence will be studied.